Polymorphism
Lack of association of the G22A polymorphism of the ADA gene in patients with ankylosing spondylitis
Authors: U. Camargo, R.A. Toledo, J.R. Cintra, D.P.T. Nunes, R. Acayaba de Toledo, C.C. Brand�£o de Mattos and L.C. Mattos
Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.7.3
- DOI:
- 10.4238/2012.May.7.3
Effect of GJB2 235delC and 30-35delG genetic polymorphisms on risk of congenital deafness in a Chinese population
Authors: Y. Xiong, M. Zhong, J. Chen, Y.L. Yan, X.F. Lin and X. Li
Congenital deafness is a serious and irreversible condition in humans. The GJB2 gene is implicated in the pathogenesis of autosomal recessive nonsyndromic hearing loss. Its 235delC and 30-35delG polymorphisms are reported to be associated with risk of hereditary deafness. However, the effect of the interaction between GJB2 235.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019165
- DOI:
- 10.4238/gmr16019165
Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis
Authors: J.Y. Ban, J.I. Shin and C.-H. Oh
The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.11
- DOI:
- 10.4238/2015.October.29.11
Development and characterization of microsatellite markers for the endangered Chinese yew Taxus chinensis var. mairei (Taxaceae)
Authors: H. Xue, C.H. Lu and X.B. Wu
We isolated and characterized 11 microsatellite loci for the Chinese yew, Taxus chinensis var. mairei, an endangered tree species in China, by constructing a (CA)12-enriched library. The number of alleles per locus ranged from 5 to 10. The observed heterozygosities ranged from 0.2500 to 0.8333 and the expected heterozygosities.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.14.3
- DOI:
- 10.4238/2012.May.14.3
Absence of SH2B3 mutation in nonobese diabetic mice
Authors: Y.J. Li, X.Y. Li, X.R. Guo, Y. Li, B.F. Shen, Y.C. Shi and J.Y. Zhang
Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.9.6
- DOI:
- 10.4238/2012.May.9.6
Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women
Authors: M.P. Gallegos-Arreola, L.E. Figuera-Villanueva, A.M. Puebla-P�©rez, H. Montoya-Fuentes, A.E. Suarez-Rincon and G.M. Z�º�±iga-Gonz�¡lez
The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.10
- DOI:
- 10.4238/2012.May.15.10
Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han
Authors: C. Lu, Y.-J. Shen, Y.-F. Deng, C.-Y. Wang, G. Fan1, Y.-Q. Liu, S.-M. Zhao, B.-C. Zhang, Y.-R. Zhao, Z.-E. Wang, C.-Z. Zhang and Z.-M. Lu
Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese H.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.7
- DOI:
- 10.4238/2012.May.15.7
A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population
Authors: Q. Ren, B. Xu, S.Q. Chen, Y. Yang, C.Y. Wang, Y.D. Wang, X.H. Wang, L.X. Hua and M. Chen
Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.5
- DOI:
- 10.4238/2012.May.15.5
Development of 18 microsatellite loci for the freshwater snail Bellamya aeruginosa (Mollusca, Gastropoda)
Authors: Q.H. Gu, B.X. Xiong, Y.T. Zhu, Q. Wang and P.S. Shi
Although it is a major freshwater gastropod species, genetic diversity of Bellamya aeruginosa was completely unknown. Eighteen microsatellite loci were isolated and characterized from (AC)15-enriched genomic libraries of the freshwater snail B. aeruginosa. Most of the 18 loci were successfully amplified and high polymorphic information content values were.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.4
- DOI:
- 10.4238/2012.May.18.4
Meta-analysis of TP73 polymorphism and cervical cancer
Authors: H. Feng, L. Sui, M. Du and Q. Wang
The aim of this study was to investigate the tumor protein p73 (TP73) G4C14-A4T14 polymorphism and to perform a meta-analysis to assess TP73 expression in cervical cancer and precancerous tissue. Articles containing data regarding TP73 status in cervical cancer patients and healthy controls were retrieved from PubMed, EMBASE, .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16016571
- DOI:
- 10.4238/gmr16016571