Polymorphism
A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations
Authors: Y. Feng, J. Sun, L. Wang, X.L. Hou
Atrial fibrillation (AF) occurrence has a known genetic component. Many reports have revealed a correlation between gene mutation and AF, involving genes related to ion channels, connexin (Cx), and those within the angiotensin system. In this study, the correlation between the Cx 40 polymorphism (rs35594137) and AF was in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.22
- DOI:
- 10.4238/2015.December.1.22
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people
Authors: X. Wang, K.W. Ma, Y.G. Zhao, G.J. Wang, W. Li
Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nucleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.3
- DOI:
- 10.4238/2015.December.1.3
Meta-analysis demonstrates association of the TGF-�²1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations
Authors: H. Wang P. Li Z.-C. Feng
There are conflicting reports associating the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy. We investigated this association through a meta-analysis. Case-control studies were searched up to January 2012; the genotype frequencies in the control group were found to be consistent with Hardy-Weinberg equilibrium. Publication bi.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.8.8
- DOI:
- 10.4238/2013.February.8.8
FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III
Authors: C.J.C. Addobbati, J. de Azev�ªdo Silva, N.A.C. Tavares, J. Ara�ºjo, R.L. Guimar�£es, L. Brand�£o, S. Crovella and P. Sandrin-Garcia
The present study investigates the effects of electroacupuncture (EA) on urinary bladder pressure (UBP) in patients with acute gastrointestinal injury (AGI). Twenty patients with AGI admitted to the First Hospital of Jiaxing intensive care unit from December 2011 to June 2013 were evaluated. Conventional group patients (n = 10) were administered moderate .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.4
- DOI:
- 10.4238/2015.January.15.4
Distribution of mating-type alleles and M13 PCR markers in the black leaf spot fungus Mycosphaerella fijiensis of bananas in Brazil
Authors: C.B. Queiroz E.C. Miranda R.E. Hanada N.R. Sousa L. Gasparotto M.A. Soares G.F. Silva
The fungus Mycosphaerella fijiensis is the causative agent of black sigatoka, which is one of the most destructive diseases of banana plants. Infection with this pathogen results in underdeveloped fruit, with no commercial value. We analyzed the distribution of the M. fijiensis mating-type system and its genetic variability using M13 phage DNA markers. We fo.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.8.9
- DOI:
- 10.4238/2013.February.8.9
Next-generation sequencing analysis of the ARMS2 gene in Turkish exudative age-related macular degeneration patients
Authors: H. Bardak, M. Gunay, Y. Ercalik, Y. Bardak, H. Ozbas and O. Bagci
Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. It is a complex disease with both genetic and environmental risk factors. To improve clinical management of this condition, it is important to develop risk assessment and prevention strategies for environmental influences, and esta.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019135
- DOI:
- 10.4238/gmr16019135
Identification of polymorphisms and transcriptional activity of the proto-oncogene KIT located on both autosomal and B chromosomes of the Chinese raccoon dog
Authors: Y.M. Li1, Y. Zhang1, W.J. Zhu1, S.Q. Yan1 and J.H. Sun2
B chromosomes are dispensable and co-exist with autosomal and sex chromosomes. The karyotype of the Chinese raccoon dog (Nyctereutes procyonoides procyonoides) comprises 0-4 B chromosomes. The proto-oncogene KIT is found on all B chromosomes of the Chinese raccoon dog. In the present study, partial DNA and mRNA sequences of KIT were amplified and sequence.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017398
- DOI:
- 10.4238/gmr.15017398
Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking
Authors: T.M. Silva, C.R. Marques, M.F. Marques Filho, A.B. Marques, G. Di Pietro and F. Rios-Santos
Polymorphisms in genes encoding xenobiotic-metaboli- zing enzymes might explain differences in the susceptibility to upper aerodigestive tract (UADT) cancers in individuals exposed to tobacco or other carcinogens. The present study aimed to evaluate the association of polymorphisms in the glutathione S-transferase (GST) candid.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.21.22
- DOI:
- http://dx.doi.org/10.4238/2014.January.21.22
PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients
Authors: Y.C. Ren1,2*, T.B. Jin1,2,4,5*, X.D. Sun6, T.T. Geng2,3*, M.X. Zhang1,2, L. Wang4,5,T. Feng2, L.L. Kang4,5 and C. Chen1,2
Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolism-related quantitative phen.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017447
- DOI:
- 10.4238/gmr.15017447
Isolation and characterization of novel microsatellite markers for molecular genetic diversity in Siganus fuscescens
Authors: Y.F. Ning, Z.B. Li, Q.H. Li, G. Dai, J.B. Shangguan, Y. Yuan and Y.S. Huang
The rabbitfish Siganus fuscescens is an economically valuable species that is widely distributed throughout the estuaries, intertidal, and offshore coasts of the Indo-Pacific and eastern Mediterranean. Ten novel microsatellite loci from the genome of S. fuscescens were developed using the fast isolation protocol with amplified fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.11
- DOI:
- 10.4238/2015.January.15.11