Polymorphism
Genetic variability of XRCC1 influences the treatment outcome of gastric cancer
Authors: H.Q. Hu1, F. Wang2, X. Du2, X.Z. Zhao2, Z. Jin2 and M.X. Hou2
We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017452
- DOI:
- 10.4238/gmr.15017452
Characterization of chicken natural resistance-associated macrophage protein encoding genes (Nramp1 and Nramp2) and association with salmonellosis resistance
Authors: X.M. He M.X. Fang Z.T. Zhang Y.S. Hu X.Z. Jia D.L. He S.D. Liang Q.H. Nie X.Q. Zhang
Natural resistance-associated macrophage protein 1 and 2 encoding genes (Nramp1 and Nramp2) are related to many diseases. We cloned the cDNA of chicken Nramp1 and Nramp2 genes, characterized their expression and polymorphisms, and investigated the association of some SNPs with resistance to salmonellosis. The Nramp1 cDNA was 1746 bp long and the Nramp2 cD.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.30.5
- DOI:
- 10.4238/2013.January.30.5
Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer
Authors: M.A. Rosales-Reynoso, L.I. Wence-Chavez, A.R. Arredondo-Valdez,S. Dumois-Petersen, P. Barros-NÃ?ºÃ?±ez, M.P. Gallegos-Arreola, S.E. Flores-MartÃ?Ânez and J. SÃ?¡nchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metab.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019324
- DOI:
- 10.4238/gmr16019324
Association of liver X receptor �± (LXR�±) gene polymorphism and ischemic stroke
Authors: H.X. Wang, K. Zhang, L. Zhao, J.W. Tang, L.Y. Gao and Z.P. Wei
We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.14
- DOI:
- 10.4238/2015.January.15.14
Polymorphic microsatellite loci for the razor clam, Sinonovacula constricta
Authors: H.-T. Ma, H.-B. Jiang, X.-Q. Liu, X.-P. Wu and X.-M Wei
The razor clam, Sinonovacula constricta, is an important commercial bivalve and a popular mollusca food in China. Twelve polymorphic microsatellite markers were isolated from the razor clam using a partial genomic library enriched for tandem repeat sequences of (CA)16, (GA)16. Polymorphisms of these loci were evaluated in a wild population of 30 individua.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.17
- DOI:
- 10.4238/2015.January.15.17
Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis
Authors: Y. Liu, X.L. Song, G.L. Zhang, A.M. Peng, P.F. Fu, P. Li, M. Tan, X. Li, M. Li and C.H. Wang
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.19
- DOI:
- 10.4238/2015.January.15.19
Isolation and characterization of novel polymorphic microsatellite loci in Perinereis aibuhitensis
Authors: Y. Liu, D. Yu, Q. Wang, H. Liu, S. Guan and M. Liu
Perinereis aibuhitensis is a commercially and ecologically important intertidal worm. In this study, eight polymorphic microsatellite loci were isolated in this species for the first time, and a wild population was used to estimate the properties of these loci. The number of alleles per locus ranged from 6 to 20, and the observed and expected heterozygosi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017144
- DOI:
- 10.4238/gmr.15017144
Genetic variability of CYP3A4 in a heterogeneous Brazilian population from Maranh�£o
Authors: S.C. Moutinho Monteiro1, I.H. de Sousa1, I.K. Pereira Belfort1,J.D. Nunes1, B.A. Sousa Penha1, M. dos Santos2, I. Drumond Louro3 and I.D.C. Guerreiro da Silva4
Inter-individual variability in drug metabolism may result in adverse drug responses. Pharmacogenetic studies have shown that polymorphisms in drug metabolizing enzymes may contribute to this variability. Among these enzymes, CYP3A4 is responsible for metabolizing over 50% of the clinically used drugs. The Brazilian population is composed of people with N.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017275
- DOI:
- 10.4238/gmr.15017275
Relationship between 5-HTTLPR polymorphism and post-stroke depression
Authors: W.Y. Guo1,4*, Z.H. Zhang2*, J.L. Mu3, D. Liu3, L. Zhao2, Z.Y. Yao4,5 and J.G. Song3
Post-stroke depression (PSD) is a mental illness characterized by subjective feelings of depression, cognitive dysfunction, and decreased interest. The serotoninergic system is involved in the pathogenesis of depressive disorders and is regulated by the serotonin transporter gene. The serotonin transporter-linked polymorphic region (5-HTTLPR) has been exa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017460
- DOI:
- 10.4238/gmr.15017460
Genetic association between the HLA-G 14-bp insertion/deletion polymorphism and the recurrent spontaneous abortions in Saudi Arabian women
Authors: S.Y. Al Omar, L. Mansour, A.F. Alkhuriji, S. Alwasel and S. Al-Qahtani
The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localiz.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.2
- DOI:
- 10.4238/2015.January.23.2