Polymorphism
Bovine dopamine receptors DRD1, DRD4, and DRD5: genetic polymorphisms and diversities among ten cattle breeds
Authors: A.M. Sifuentes-Rinc�³n1, A.G. Trejo-Tapia1, R.D. Randel2, P. Ambriz-Morales1 and G.M. Parra-Bracamonte1
The aim of this study was to analyze the allelic frequency distribution and segregation among breeds and/or between different cattle genetic groups of four novel single nucleotide polymorphisms of the bovine DRD1 and DRD5 genes and one reported SNP from the DRD4 gene. One hundred and nine-animals from ten different cattle breeds were genotyped and allelic.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017725
- DOI:
- 10.4238/gmr.15017725
IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B
Authors: L.N. Cao1, S.L. Cheng2 and W. Liu3
We conducted a case-control study to assess the role of two IL10 gene polymorphisms (rs1800896 and rs1800872) in susceptibility to liver cirrhosis, and their association with chronic hepatitis B in a Chinese population. A case-control study was designed to investigate the association between functional polymorphisms of IL10 (rs1800896 and rs1800872) and t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017256
- DOI:
- 10.4238/gmr.15017256
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population
Authors: D.Z. Tian, W. Wei and Y.J. Dong
ype I collagen (transcribed by COL1A1 and COL1A2 genes) is important for maintaining vessel wall elasticity and is a critical part of the extracellular matrix. We conducted a case-control study to investigate the role of the COL1A2 rs42524 polymorphism in the development of hypertensive intracerebral hemorrhage. Between January 2012 and December 2014, a t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017369
- DOI:
- 10.4238/gmr.15017369
Marker-trait association analysis for agronomic and compositional traits in sainfoin (Onobrychis viciifolia)
Authors: K. Kempf, C.S. Malisch, C. Grieder, F. Widmer and R. K�¶lliker
Sainfoin (Onobrychis viciifolia) is a perennial forage legume with great potential for use in sustainable agriculture due to its low input requirements, good drought tolerance, and production of forage rich in polyphenolic compounds, which are beneficial for animal health. However, its distribution and cultivation are limited .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019483
- DOI:
- 10.4238/gmr16019483
Molecular cloning and expression pattern of the porcine 5-aminolevulinate synthase 1 (ALAS1) gene and its association with reproductive traits
Authors: L.Q. Liu1, F.E. Li2 and C.Y. Deng2
5-Aminolevulinate synthase 1 (ALAS1) is the first enzyme in the heme biosynthetic pathway and is upregulated in follicular tissue during the early stages of ovulation. In this study, we isolated the complete coding sequence of the porcine ALAS1 gene and its 2-9 intron sequence, identified a single nucleotide polymorphism (SNP; T/C) in intron 9, and develo.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017544
- DOI:
- 10.4238/gmr.15017544
Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population
Authors: J.M. Liu J.N. Liu M.T. Wei Y.Z. He Y. Zhou X.B. Song B.W. Ying J. Huang
Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs194651.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.March.15.2
- DOI:
- 10.4238/2013.March.15.2
Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes
Authors: S.W. Souza, L.P. Alcazar, P.A. Arakaki, I.C.R. Santos-Weiss, D. Alberton, G. Picheth and F.G.M. Rego
Insulin secretion is regulated by ATP-sensitive potassium channels (KATP). The potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, located on chromosome 11p15.1, encodes the subunit Kir6.2 that forms the pore region of KATP channels in pancreatic β-cells. Among the single nucleotide polymorphisms .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029543
- DOI:
- 10.4238/gmr16029543
Dietary carotenoid-rich pequi oil reduces plasma lipid peroxidation and DNA damage in runners and evidence for an association with MnSOD genetic variant -Val9Ala
Authors: A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, L.C.S. Pereira,C.A. Gon�§alves, M.N. Klautau-Guimar�£es and C.K. Grisolia
Physical training induces beneficial adaptations; however, exhausting exercise increases reactive oxygen species generation, resulting in damage to DNA and tissues. Pequi (Caryocar brasiliense), a fruit of the Brazilian Cerrado, contains a carotenoid-rich oil. We investigated whether pequi oil had antioxidant effects in runner.. Read More»
- Genet. Mol. Res. 8(4):
Association between TNF-�±rs1799724 and rs1800629 polymorphisms and the risk of Crohnâ��s disease
Authors: Y.Q. Mao, S.Q. Dong, M. Gao
We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.33
- DOI:
- 10.4238/2015.December.1.33
XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia
Authors: J.P. Meza-Espinoza, V. Peralta-Leal, M. Gutierrez-Angulo,N. Macias-Gomez, M.L. Ayala-Madrigal, P. Barros-Nu�±ez,J. Duran-Gonzalez and E. Leal-Ugarte
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain rea.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr687
- DOI:
- 10.4238/vol8-4gmr687