Polymorphism
Molecular characterization, tissue expression, and polymorphism analysis of liver-type fatty acid binding protein in Landes geese
Authors: Z. Song, D. Shao, X.X. Sun, J.W. Niu and D.Q. Gong
Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-F.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.12
- DOI:
- 10.4238/2015.January.23.12
Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women
Authors: J. Chen, M. Zhong and Y.H. Yu
Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. In this study, we investigated the relationship between IL-4 C-590T, C+33.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029218
- DOI:
- 10.4238/gmr16029218
Polymorphism analysis of the intron one of insulin-like growth factor 2 receptor gene (IGF2R) in FFRC strain common carp (Cyprinus carpio L.) and its relationship with growth performance
Authors: Z.J. Dong, S.Y. Su, W.B. Zhu, C.F. Zhang, M. Ding, W.X. Chen, X.H. Yuan and Z. Xie
The insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor and acts to sequester and degrade excess circulating insulin-like growth factor 2, which is critical for normal mammalian growth and development. Thus, IGF2R may serve as a candidate gene underlying growth trait in the common carp. In this study, we isolated th.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.14
- DOI:
- 10.4238/2015.January.23.14
Role of GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms in the response to chemotherapy and overall survival of advanced non-small cell lung cancer
Authors: W. Jia, J.Y. Sun, K.Y. Jia and X.C. Liu
We evaluated the association between GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and treatment outcomes of advanced non-small cell lung carcinoma. Between January 2010 and December 2012, a total of 244 patients with non-small cell lung carcinoma were recruited from Yiwu Central Hospital. The GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms we.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037668
- DOI:
- 10.4238/gmr.15037668
Duplication polymorphisms in exon 4 of �º-casein gene in yak breeds/populations
Authors: S. Pingcuo, J. Gao, Z.R. Jiang, S.Y. Jin, C.Y. Fu, X. Liu, L. Huang and Y.C. Zheng
The objective of this study was to compare 12 bp-duplication polymorphisms in exon 4 of the κ-casein gene among 3 breeds/populations of yak (Bos grunniens). Genomic DNA was extracted from yak blood or muscle samples (N = 211) and a partial sequence of exon 4 of κ-casein gene was amplified by polymerase chain reaction. A polyacrylamide gel elec.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.August.28.8
- DOI:
- http://dx.doi.org/10.4238/2015.August.28.8
Polymorphism and haplotype analyses of swine leukocyte antigen DQA exons 2, 3, 4, and their associations with piglet diarrhea in Chinese native pig
Authors: X.Y. Huang, Q.L. Yang, J.H. Yuan and S.B. Gun
In this study, 290 Chinese native Yantai black pig piglets were investigated to identify gene polymorphisms, for haplotype reconstruction, and to determine the association between piglet diarrhea and swine leukocyte antigen (SLA) class II DQA exons 2, 3, and 4 by polymerase chain reaction-single stranded conformational polymorphism and cloning sequencing... Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.7
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.7
Molecular characterization of olive cultivars using amplified fragment length polymorphism markers
Authors: S. Ercisli, E. Barut and A. Ipek
We sampled six olive cultivars (Tavli Sati, Sati, Gorvela, Sacakli Otur, Butko, and Otur) from Coruh Valley, located in the northeast part of Turkey, and characterized them using amplified fragment length polymorphism (AFLP) markers. Some morphological and biochemical characteristics are also determined. Six AFLP primer combin.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr576
- DOI:
- 10.4238/vol8-2gmr576
Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles
Authors: T. Nakamura, N. Okamura, M. Yagi, H. Omatsu, M. Yamamori,A. Kuwahara, K. Nishiguchi, M. Horinouchi, K. Okumura and T. Sakaeda
ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle w.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr574
- DOI:
- 10.4238/vol8-2gmr574
DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population
Authors: J.Y. Huang, J.F. Yang, Q. Qu, J. Qu, F. Liu, F.E. Liu, T. Xiong and S.H. Lu
The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma pati.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.18
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.18
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Authors: L. Yang, X.W. Wang, L.P. Zhu, H.L. Wang, B. Wang, T. Wu, Q. Zhao, D.L.X.T. JinSiHan and X.Y. Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorph.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038679
- DOI:
- 10.4238/gmr.15038679