Polymorphism
Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies
Authors: W.H. Ren, D.K. Jiang, Y. Pei, S.Q. Wang, X.M. Yang and L. Yu
Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) t.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.9
- DOI:
- 10.4238/2014.January.8.9
Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma
Authors: H.F. Zhang, J.P. Yan, Y.S. Zhuang and G.Q. Han
The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C a.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.14
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.14
No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area
Authors: J.L. Li, Y.J. Li, K.J. Zhang, L. Lan, J.G. Shi, X. Yang, M.J. Zhang, F.C. Zhang and X.C. Gao
FGD1 encoding a guanine nucleotide exchange factor, specifically activates Rho GTPase cell division cycle 42 (Cdc42). Dysfunction of FGD1 causes Aarskog-Scott syndrome (MIM #305400), an X-linked disorder that may affect bone and intellectual development. However, the relationship between FGD1 and intellectual developmental dis.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.3
- DOI:
- 10.4238/2014.January.10.3
-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race
Authors: S. Mandal, F. Abebe and J. Chaudhary
Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation cou.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.5
- DOI:
- 10.4238/2014.January.10.5
Analysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis
Authors: C.L. Ribeiro J�ºnior, J.T. Arruda, C.T.X. Silva andK.K.V.O. Moura
We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two gro.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr593
- DOI:
- 10.4238/vol8-2gmr593
Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population
Authors: X.J. Zhu, W.Z. Li, H. Li, C.Q. Fu and J. Liu
The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured.. Read More»
- Genet. Mol. Res. 16(2):
Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population
Authors: X.F. Li, Y.X. Chen, W.W. Ye, X.F. Tao, J.H. Zhu, S. Wu and L.Q. Lou
The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.7
- DOI:
- 10.4238/2014.January.10.7
Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese
Authors: L. Xiao, L.B. Gao and Q. Wei
The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.8
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.8
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Authors: F.L. Campedelli, K.S.F. e Silva, D.A. Rodrigues, J.V.M. Martins, I.R. Costa, M.H. Lagares, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alteratio.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029550
- DOI:
- 10.4238/gmr16029550
Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis
Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang
Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.16