Polymorphism
Study of genetic variability in pigs after the traditional breeding program
Authors: I.M. Ferreira, G.S. Vieira, T.F. Braga, T.C.F. Silva, M.M. Franco and R.C. Antunes
Molecular markers are tools used to improve genetic gains. The objective of this study was to analyze the security of alleles of molecular marker genes for characteristics of economic interest in a pure population of pigs. After the extraction of DNA from the hair of 272 Large White matrices, the allele and genotype frequency .. Read More»
- Genet. Mol. Res. 16(3):
Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes
Authors: Y. Al-Lahham, A.K.B. Mendes, E.M. Souza, D. Alberton, F.G.M. Rego, G. Valdameri and G. Picheth
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transp.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039755
- DOI:
- 10.4238/gmr16039755
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism
Authors: A.M. Barbosa, K.S.F. Silva, M.H. Lagares, D.A. Rodrigues,I.R. da Costa, M.P. Morais, J.V.M. Martins, R.S. Mascarenhas, F.L. Campedelli and K.K.V.O. Moura
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening cli.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039708
- DOI:
- 10.4238/gmr16039708
Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer
Authors: A.Q. Niu, Y.H. Cao, H. Wang, X. Zhang, B. Zhu and Z.H. Li
Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038826
- DOI:
- 10.4238/gmr16038826
Polymorphisms of interleukin 6 in Down syndrome individuals: a case-control study
Authors: M.F. Mattos, L. Uback, P.M. Biselli-Chicote, J.M. Biselli, E.M. Goloni-Bertollo and E.C. Pavarino
Down syndrome (DS) individuals present impaired adaptive immune system. However, the etiology of the immunological deficiency in these individuals is not completely understood. This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals witho.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039738
- DOI:
- 10.4238/gmr16039738
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
Authors: M.H. Lagares, K.S.F. Silva, A.M. Barbosa, D.A. Rodrigues, I.R. Costa, J.V.M. Martins, M.P. Morais, F.L. Campedelli and K.K.V.O. Moura
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subseq.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039721
- DOI:
- 10.4238/gmr16039721
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039697
- DOI:
- 10.4238/gmr16039697
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Authors: E.V.W. dos Santos, L.N.R. Alves and I.D. Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instab.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039691
- DOI:
- 10.4238/gmr16039691
Genetic variability of a Brazilian Capsicum frutescens germplasm collection using morphological characteristics and SSR markers
Authors: S.I.C. Carvalho, L.B. Bianchetti, C.F. Ragassi, C.S.C. Ribeiro, F.J.B. Reifschneider, G.S.C. Buso and F.G. Faleiro
Characterization studies provide essential information for the conservation and use of germplasm in plant breeding programs. In this study, 103 Capsicum frutescens L. accessions from the Active Germplasm Bank of Embrapa Hortaliças, representative of all five Brazilian geographic regions, were characterized based on morp.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039689
- DOI:
- 10.4238/gmr16039689
Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand
Authors: A. Tungtrongchitr, J. Jumpasri, N. Sookrung, N. Visitsunthorn, P. Tantilipikorn, O. Piboonpocanan, N. Indrawattana, R. Tungtrongchitr and W. Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled st.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039641
- DOI:
- 10.4238/gmr16039641