Polymorphism
Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis
Authors: M. Zhai, Y. Wang and M.F. Jiang
Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.19
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.19
New polymorphisms in the novel LYRM1 gene are associated with body measurement and meat quality traits in Qinchuan cattle
Authors: Y.K. Li, Y.F. Huangpu, J.B. Gao, N. Yang, C.Z. Fu, H.B. Wang, G. Cheng and L.S. Zan
Body measurement and meat quality traits play important roles in the evaluation of productivity in cattle; they are influenced by genetic and environmental factors. Recent studies have shown that LYRM1 is a novel gene related to obesity and may influence fat deposition. We screened for new polymorphisms in the bovine LYRM1 gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.12.18
- DOI:
- 10.4238/2014.March.12.18
Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility
Authors: S.-S. Li, J. Li, Z. Xiao, A.-G. Ren and L. Jin
The aim of this study was to explore the relationship between 2 genetic polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR), C677T and A1298C, and determine the long-term reproductive outcome in infertile men. This was a prospective study conducted in an andrology clinic. Men with a 1-year history of.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.24.26
- DOI:
- 10.4238/2014.March.24.26
Novel non-synonymous polymorphisms in the COX-1 gene in Turkish pediatric patients with cardiovascular anomalies
Authors: Coskun, Y. Colkesen, F. Ayik A. Berdeli and Y. Atay
Variation in the gene encoding cyclooxygenase-1 (COX-1) is involved in the process of aspirin resistance. This study investigated the genetic variations in the COX-1 gene. The 4 coding regions of the human COX-1 gene in 90 pediatric patients (median age of 6.5 months, 55% males) with cardiovascular anomalies were screened using DNA sequencing. Twenty codi.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.10
- DOI:
- 10.4238/2014.January.17.10
B chromosome prevalence and physical mapping of 18S rDNA and H4 histone sites in the grasshopper Xyleus discoideus angulatus (Romaleidae)
Authors: C.B. Machado, L.C. Silva Neto, V. Loreto and M.J. Souza
We sampled 11 natural populations of the grasshopper Xyleus discoideus angulatus in Northeastern Brazil to analyze B chromosome frequency and meiotic behavior. We observed a single large B chromosome, resembling the X chromosome, in 29 of the 402 specimens. Eight of the 11 populations had B chromosomes, with a rather .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.March.26.4
- DOI:
- 10.4238/2014.March.26.4
Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese
Authors: Y. Cheng, M.W. Li, H.P. Li, W.T. Zeng, P. Zhou, L.Z. Huang, X.X. Li and Y.Y. Sun
Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.17.15
- DOI:
- 10.4238/2014.January.17.15
Genetic and epigenetic status of triple exotic consanguinity cotton introgression lines
Authors: S.P. He, J.L. Sun and X.M. Du
Introgression lines are some of the most important germplasm for breeding applications and other research conducted on cotton crops. The DNA methylation level among 10 introgression lines of cotton (Gossypium hirsutum) and three exotic parental species (G. arboreum, G. thurberi and G. barbadense) were assessed by methylation-s.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.1
- DOI:
- 10.4238/2011.October.3.1
Matrix metalloproteinase-3 gene polymorphism and its mRNA expression in rheumatoid arthritis
Authors: M.J. Ma, H.C. Liu, X.Q. Qu, J.L. Wang
Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.17
- DOI:
- 10.4238/2015.December.1.17
Polymorphisms associated with egg number at 300 days of age in chickens
Authors: H.P. Xu, H. Zeng, D.X. Zhang, X.L. Jia, C.L. Luo, M.X. Fang, Q.H. Nie and X.Q. Zhang
We looked for variations that could be associated with chicken egg number at 300 days of age (EN300) in seven genes of the hypothalamic-pituitary-gonadal axis, including gonadotrophin-releasing hormone-I (GnRH-I), GnRH receptor (GnRHR), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP),.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.5
- DOI:
- 10.4238/2011.October.3.5
Association of a transforming growth factor-�²1 polymorphism with acute coronary syndrome in a Chinese Han population
Authors: Y.N. Yang, B. Zhao, X.M. Li, X. Xie, F. Liu and B.D. Chen
Acute coronary syndrome (ACS) is a complex multifactorial and polygenic disorder that is thought to result from the interaction between an individual’s genetic makeup and various environmental factors. The aim of this study was to investigate the association of a transforming growth factor-β1 (TGF-β1) polymorph.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.3.2
- DOI:
- 10.4238/2014.April.3.2