Polymorphism
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population
Authors: Q. Zhong, R.R. Wu and Z.M. Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038682
- DOI:
- 10.4238/gmr.15038682
Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population
Authors: H.C. Liu, J. Zhang, S. Wong, D. Han, H.S. Zhao and H.L. Feng
Tooth agenesis is one of the most common anomalies of human dentition. Recent genetic studies have provided information regarding a number of genes related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.3.4
- DOI:
- 10.4238/2014.April.3.4
Development and characterization of single nucleotide polymorphism markers in Camellia sinensis (Theaceae)
Authors: C.C. Zhang, L.Y. Wang, K. Wei and H. Cheng
Tea is the second most popular non-alcoholic beverage in the world. In recent years, several molecular markers have been used in genetic studies of the tea plant. Yet, only a few single nucleotide polymorphisms (SNPs) have been reported. Here, we identified 818 putative SNPs from expressed sequence tag (EST) databases for the .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.10
- DOI:
- 10.4238/2014.April.14.10
Role of inflammatory parameters in the susceptibility of cerebral thrombosis
Authors: X.F. Qi, T.J. Feng, P. Yang, H.Y. Feng, P. Zhang, L.Y. Kong, D.L. Liang, P.F. Li, W. Na, Y.W. Li and Y. Wang
We aimed to investigate the association of inflammation-related genes such as IL-10, IL-6 and IL-1B with risk of ischemic stroke. We included 426 cases with ischemic stroke and 426 health controls from Xinxiang, China. Genomic DNA was extracted from the buffy coat layer of collected blood with the TIANamp blood DNA kit. Diabet.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.16.1
- DOI:
- 10.4238/2014.April.16.1
Meta-analysis of the relationship between p21 Ser31Arg polymorphism and lung cancer susceptibility
Authors: G. Lin, F. Fang, X.-J. Yu and L. Yu
The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stra.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.13.2
- DOI:
- 10.4238/2011.October.13.2
Esterase polymorphisms for analysis of genetic diversity and structure of soybean (Glycine max) cultivars
Authors: L.C. Valentini, C.A. Mangolin, S.A.O. Collet and M.F.P.S. Machado
We used native polyacrylamide gel electrophoresis to identify polymorphism levels in a- and b-esterase loci from leaf tissues of Brazilian soybean cultivars for the analysis of population genetic diversity and structure, and to investigate relationships between conventional and genetically modified cultivars. The cultivars inc.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.13.4
- DOI:
- 10.4238/2011.October.13.4
A novel single-nucleotide polymorphism in the 5' upstream region of the prolactin receptor gene is associated with fiber traits in Liaoning cashmere goats
Authors: J.P. Zhou, X.P. Zhu, W. Zhang, F. Qin, S.W. Zhang and Z.H. Jia
The most important traits of Chinese Liaoning cashmere goat fiber are fiber diameter, weight, and length. We looked for polymorphisms and their possible association with cashmere fiber traits in the 5' upstream region (5' UTR) of the prolactin receptor gene (PRLR), which encodes an anterior pituitary peptide hormone involved i.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.13.8
- DOI:
- 10.4238/2011.October.13.8
Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation
Authors: B. Eser, O. Eser, Y. Yuksel, H. Aksit, E. Karavelioglu, M. Tosun and Z. Sekerci
The aim of this study was to identify the possible correlation between polymorphisms in matrix metalloproteinase (MMP)-1 and MMP-3 and their corresponding protein levels in disctissues obtained from patients with lumbar disc herniation (LDH) using biochemical and immunohistochemical analyses. Blood and disc samples were obtained from 100 patients with LDH.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038669
- DOI:
- 10.4238/gmr.15038669
Common ABCB1 polymorphisms associated with susceptibility to infantile spasms in the Chinese Han population
Authors: L. Dong, M. Mao, R. Luo, Y. Tong and D. Yu
Infantile spasms are a severe epileptic encephalopathy with a variety of etiologies that occur in infancy and early childhood. Subjects with infantile spasms are at a higher risk for evolving into intractable epileptic spasms, tending to be refractory to conventional antiepileptic drugs. Genetic polymorphisms of the P-glycopro.. Read More»
- Genet. Mol. Res. 10(4):
- 2001.October.19.3
- DOI:
- 10.4238/2001.October.19.3
FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sj�¶grenâ��s syndrome
Authors: B.A. TreviÃ?±o-Talavera, C.A. Palafox-SÃ?¡nchez, J.F. MuÃ?±oz-Valle, G. Orozco-Barocio, R.E. Navarro-HernÃ?¡ndez, M. VÃ?¡zquez-Del Mercado, I. GarcÃ?Âa de la Torre and E. Oregon-Romero
Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Soluble Fas receptor (sFas) has been suggested as a Fas-mediated apoptosis blocker that could impair clonal deletion in infiltrated autoreactive cells. The FAS -670A>G promoter p.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.2.12
- DOI:
- 10.4238/2014.July.2.12