Polymorphism
Interleukin-6 -572G/C polymorphism and prostate cancer susceptibility
Authors: W.J. Huan, L.J. Wu, Z.C. Min, L.T. Xu, C.M. Guo, Z.P. Chen, X.J. Lou, B. Xu3and B.D. Lv
Strong evidence suggests that cancer-associated inflammation promotes tumor growth and progression, and interleukin-6 (IL6) is an important modulator of inflammation. However, the roles of IL6 and mutations of its corresponding gene in prostate cancer have not been clearly documented. We retrieved data from the Oncomine database concerning IL6 expression .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037563
- DOI:
- 10.4238/gmr.15037563
Association of chicken growth hormone polymorphisms with egg production
Authors: Y.J. Su, J.T. Shu, M. Zhang, X.Y. Zhang, Y.J. Shan, G.H. Li, J.M. Yin, W.T. Song, H.F. Li and G.P. Zhao
Growth hormone (GH) has diverse functions in animals, together with other hormones from the somatotropic axis. Here, chicken GH (cGH) was investigated in recessive white chickens and Qingyuan partridge chickens as a candidate gene affecting egg production traits. Chicken egg production traits were studied in association with 4.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.3
- DOI:
- 10.4238/2014.July.4.3
A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population
Authors: W. Zeng, L. Liu, Y. Tong, H.M. Liu, L. Dai and M. Mao
Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.25.7
- DOI:
- 10.4238/2011.October.25.7
Correlation between polymorphisms in the estrogen receptor �± gene and coronary heart disease: A meta-analysis
Authors: W. Zhou, K.H. He and M.H. Chen
The aim of this study was to conduct a systematic evaluation the correlation between polymorphisms in the estrogen receptor α gene (ESRα) and coronary heart disease susceptibility. Case-control studies until August 2015 analyzing the correlation between the ESRα PvuII T/C polymorphism and coronary heart disease were obtained from various.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037835
- DOI:
- 10.4238/gmr.15037835
Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays
Authors: Y.D. Apalasamy , F.M. Moy, S. Rampal, A. Bulgiba and Z. Mohamed
A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.4
- DOI:
- 10.4238/2014.July.4.4
Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome
Authors: L. Wei, Y. An and J. Wang
Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038401
- DOI:
- 10.4238/gmr.15038401
Clinical study of the correlation between complement factor H polymorphism and age-related macular degeneration
Authors: H.T. Dong, J.X. Zhang, Q.M. Li and F.Z. Li
This study aimed to investigate the correlation between age-related macular degeneration (AMD) of the liver-kidney yin-deficiency type and complement factor H (CFH) polymorphism, and to determine whether the C allele of the T1277C (Y402H) variant is a risk factor for this condition. We performed a case-control investigation of 60 patients with liver-kidne.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038457
- DOI:
- 10.4238/gmr.15038457
Effect of pregnane X receptor polymorphisms on tacrolimus blood concentrations and the resulting adverse reactions in kidney transplantation recipients
Authors: Z.P. Wang, M. Zhao, Q.S. Qu and S.Z. Miao
We investigated the effect of pregnane X receptor (PXR) polymorphisms on tacrolimus (FK506) blood trough concentrations and the associated adverse reactions in kidney transplantation recipients (KTRs). Polymerase chain reaction (PCR)-restriction fragment length polymorphism was used to detect the genotypes of single nucleotide polymorphism loci in 336 KTR.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038464
- DOI:
- 10.4238/gmr.15038464
Associations of serotonin receptor gene HTR3A, HTR3B, and HTR3A haplotypes with bipolar disorder in Chinese patients
Authors: J. Jian, C. Li, J. Xu, D. Qiao, G. Mi, X. Chen and M. Tang
Single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B have been reported to be associated with bipolar disorder in European and Japanese populations. We explored the roles of 21 tag SNPs in HTR3A and HTR3B in susceptibility to bipolar disorder in a Chinese cohort. Twenty-one Tag SNPs were genotyped in a study consisting of 130 patients with bipolar di.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038671
- DOI:
- 10.4238/gmr.15038671
Association of CD4 SNPs with fat percentage of Holstein cattle
Authors: T. Usman, Y. Yu, L. Zhai, C. Liu, X. Wang and Y. Wang
Cluster of differentiation 4 gene (CD4) is well known for its role in immunity, but its effects on production traits remain to be elucidated. The present study was designed to explore single nucleotide polymorphisms (SNPs) in the exons, flanking introns, and promoter of CD4, as well as to analyze their effects on milk production traits (percentage of prot.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038697
- DOI:
- 10.4238/gmr.15038697