Polymorphism
TNF-�± G-308A polymorphism is associated with insulin resistance: a meta-analysis
Authors: H.G. Wang, J. Yang, H. Han, F. Xu, Y. Bian, H. Zhang and J.L. Wang
Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conflicting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE an.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.11
- DOI:
- 10.4238/2015.January.26.11
Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken
Authors: Y. Wei S.K. Zhu S. Zhang R.L. Han Y.D. Tian G.R. Sun X.T. Kang
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is rate-limiting for metabolism of cholesterol; it plays an important role in endogenous cholesterol biosynthesis. We used DNA sequencing technology and created restriction site PCR-RFLP to detect HMGCR SNPs in an F2 resource population of Gushi chicken and Anka broilers. We found a G/T mu.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.10
- DOI:
- 10.4238/2012.November.12.10
Characterization and development of 56 EST-SSR markers derived from the transcriptome of Odontobutis potamophila
Authors: P.P. Wang, M. Ren, S.Q. Chen, S.W. Yin, C. Zhao, H.Y. Zhang, X.R. Li, Q.Q. Cao and G.Q. Zhou
Expressed sequence tags (ETSs) are the sources of microsatellite development. In this study, we isolated and characterized microsatellite markers for Odontobutis potamophila by using Illumina RNA-sequencing. We sequenced a large number of ESTs and screened 200 potential microsatellites. Consequen.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029129
- DOI:
- 10.4238/gmr16029129
DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis
Authors: R.B. Ji, Y.S. Qian, A.R. Hu, Y.R. Hu
Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.11
- DOI:
- 10.4238/2015.December.7.11
Association of three common single nucleotide polymorphisms of SLC7A7 with the development of glioma in a Chinese population
Authors: H. Zhang and W.J. Shi
Gliomas are brain tumors that can be seriously damaging to human health. The SLC7 family is involved in amino acid or peptide transportation. The relationship between SLC7A7 polymorphisms and the development of glioma has been reported previously by a few studies. Therefore, we performed a hospital based case-control study to .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029026
- DOI:
- 10.4238/gmr16029026
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma
Authors: J.N. Zhang S.H. Yi X.H. Zhang X.Y. Liu Q. Mao S.Q. Li W.H. Xiong Y.M. Qiu T. Chen J.W. Ge
Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies i.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.4.9
- DOI:
- 10.4238/2012.October.4.9
Role of interleukin-6 polymorphisms in the development of allergic rhinitis
Authors: N. Zhao1,2, H.J. Liu2, Y.Y. Sun3 and Y.Z. Li1
The aim of this study was to investigate the role played by the IL-6 rs1800795 (-174G/C) and rs1800796 (-572G>C) polymorphisms in the susceptibility to allergic rhinitis in a Chinese population. A total of 265 patients with allergic rhinitis and 265 controls from our hospital were enrolled in this study. The IL-6 rs1800795 and rs1800796 polymorphisms w.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016987
- DOI:
- 10.4238/gmr.15016987
Molecular characterization, tissue expression profile, and SNP analysis of porcine SLC13A5
Authors: L.Y. Wang, J. Jiang, H.M. Ma
Solute carrier family 13 (sodium-dependent citrate transporter member 5, SLC13A5) gene has been recently found to play an important role in intramuscular fat content in pigs. In this study, the full-length cDNA of porcine SLC13A5 was obtained from the longissimus dorsi muscle of Shaziling pigs, using the rapid amplification of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.21
- DOI:
- 10.4238/2015.December.7.21
Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis
Authors: W. Chang, Q. Meng, J.H. Liu, L.X. Wu, Y. Chen,S.D. Chen
The A1298C polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be associated with hepatocellular carcinoma (HCC), but there are conflicting results from previous studies. The present study aimed to investigate the association between this polymorphism and the risk of HCC using a meta-analy.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.9
- DOI:
- 10.4238/2015.December.7.9
Associations between HLA-A\B\DRB1 polymorphisms and risks of vulvar lichen sclerosus or squamous cell hyperplasia of the vulva
Authors: G.L. Liu,F.L. Cao, M.Y. Zhao,J. Shi, S.H. Liu
In this study, we aimed to explore the associations between HLA-A\B\DRB1 polymorphisms and the risks of vulvar lichen sclerosus (VLS) or squamous cell hyperplasia of the vulva (SCHV) in Han Chinese women. We enrolled 76 Han Chinese women with VLS (Group A), 74 with SCHV (Group B), and 66 healthy women (control group) in this s.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.8
- DOI:
- 10.4238/2015.December.7.8