Polymorphism
Analysis of polymorphisms in milk proteins from cloned and sexually reproduced goats
Authors: H. Xing, B. Shao, Y.Y. Gu, Y.G. Yuan, T. Zhang, J. Zang, Y. Cheng
This study evaluates the relationship between the genotype and milk protein components in goats. Milk samples were collected from cloned goats and normal white goats during different postpartum (or abortion) phases. Two cloned goats, originated from the same somatic line of goat mammary gland epithelial cells, and three sexual.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.9
- DOI:
- 10.4238/2015.December.8.9
Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer
Authors: H. Yang, G. Li and W.F. Li
We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymeras.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.13
- DOI:
- 10.4238/2015.January.30.13
Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma
Authors: J.Y. Wang, A.L. Wang, W. Han, Z.L. Mu
Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of chi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.13
- DOI:
- 10.4238/2015.December.8.13
MKL1-184C>T gene polymorphism is associated with coronary artery diseasein the Chinese Han population
Authors: Y. Xu B. Li, Y.-Z. Bao, X.-Y. Zhang, Z.-Y. Zhu, X.-F. Zhao,Y.-N. Shi, D. Li, S.-H. Chen, Y. Guo and C.-H. Cui
We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distr.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.4
- DOI:
- 10.4238/2014.January.28.4
TGF-�²1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients
Authors: J. Ma, Y.C. Liu, Y. Fang, Y. Cao and Z.L. Liu
Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, lit.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.3
- DOI:
- 10.4238/2015.May.4.3
Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer
Authors: H.-T. Zhang, Y. Xu, Z.-H. Zhang and L. Li
Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise est.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.13
- DOI:
- 10.4238/2012.June.15.13
Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population
Authors: S.G. Liu, L. Ma, Q.H. Cen, J.S. Huang, J.X. Zhang and J.J. Zhang
Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased ris.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.4
- DOI:
- 10.4238/2015.May.4.4
Association of interleukin-1�² -511C/T promoter polymorphism with COPD risk: a meta-analysis
Authors: Y.S. Wang, L. Liu, X.Y. Xu, J.L. Wang, H. Zhou, T.L. Li and Z.A. Liang
Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sect.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.5
- DOI:
- 10.4238/2015.May.4.5
Association between macrophage migration inhibitory factor rs1007888 and GDM
Authors: Y. Zhan, C. Li, J. Chen, S. Yu, Q. Gao, Y.P. Wang and S.G. Liu
We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genot.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.4
- DOI:
- 10.4238/2015.February.2.4
A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese
Authors: L.Q. Shen, Y.Z. Xie, X.F. Qian, Z.X. Zhuang, Y. Jiao and X.F. Qi
Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let- 7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes i.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.8
- DOI:
- 10.4238/2015.May.4.8