Polymorphism
Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment
Authors: X. Ding, J.R. Yue, M. Yang, Q.K. Hao, H.Y. Xiao, T. Chen, L.Y. Gao and B.R. Dong
The aim of this study was to explore the existence of a relationship between the rs189037 single nucleotide polymorphism (SNP) of the ataxia telangiectasia mutated (ATM) gene and cognitive impairment in the elderly (aged 60 years and above). In a cohort, 505 residents of Suinung City were consecutively recruited and their cognitive function was measured u.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.17
- DOI:
- 10.4238/2015.May.4.17
Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population
Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan
We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.19
- DOI:
- 10.4238/2015.May.4.19
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer
Authors: L. Zhang, R.-X. Xi and X.-Z. Zhang
We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age- and gender-matched healthy co.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.20
- DOI:
- 10.4238/2015.May.4.20
Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population
Authors: X.H. Wang, F.R. Wang, Y.F. Tang, H.Z. Zou and Y.Q. Zhao
We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.20
- DOI:
- 10.4238/2014.July.4.20
Distribution and clinal trends of the ABO and Rh genes in select Middle Eastern countries
Authors: E.S. AlSuhaibani, N.A. Kizilbash, K. Afshan and S. Malik
An understanding of the ABO and Rh blood group systems is important for blood transfusions and is also pertinent due to their potential association with certain morbidities and susceptibilities to infections. To investigate the diversity and differentiation of the ABO and Rh loci in Middle Eastern populations, data from twelve representative Middle Easter.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.12
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.12
Association between SNPs in genes involved in folate metabolism and preterm birth risk
Authors: B.J. Wang, M.J. Liu, Y. Wang, J.R. Dai, J.Y. Tao, S.N. Wang,N. Zhong and Y. Chen
We investigated the association between 12 single nucleotide polymorphisms (SNPs) in 11 genes involved in folate metabolic and preterm birth. A subset of SNPs selected from 11 genes/loci involved in the folic acid metabolism pathway were subjected to SNaPshot analysis in a case-control study. Twelve SNPs (CBS-C699T, DHFR-c594+59del19, GST01-C428T, MTHFD-G.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.9
- DOI:
- 10.4238/2015.February.2.9
EPHX1 Tyr113His and His139Argpolymorphisms in esophageal cancer risk: a meta-analysis
Authors: X. Tan, W.W. He, Y.Y. Wang, L.J. Shi and M.W. Chen
Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) po.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.10
- DOI:
- 10.4238/2014.January.28.10
Vascular endothelial growth factor as an angiogenesis biomarker for the progression of autosomal dominant polycystic kidney disease
Authors: D.P. Martins1, M.A. Souza1, M.E. Lopes Baitello1, V. Nogueira1, C.I. Ferreira Oliveira1, M.A. de Souza Pinhel1, H.C. Caldas2, M.A. Filho2 and D.R. Silva Souza1
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary nephropathy characterized by abnormal growth of epithelial cells. Genetic factors, including the vascular endothelial growth factor (VEGF) gene, play an important role in its progression. The main aim of this study was to evaluate the influence of VEGF-C936T polymorphism in the developme.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017623
- DOI:
- 10.4238/gmr.15017623
Interleukin-10 polymorphisms associated with susceptibility to acute myeloid leukemia
Authors: C. Fei, X.M. Yao, Y. Sun, X.Z. Gu, L.Q. Yu and X. Lai
We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.15
- DOI:
- 10.4238/2015.February.2.15
Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level
Authors: X.J. Yu, B.L. Su, X.M. Wang, H.J. Feng and C.J. Jin
This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TN.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.1
- DOI:
- 10.4238/2014.July.7.1