Polymorphism
Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Authors: Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.2
- DOI:
- 10.4238/2012.November.12.2
GSTM1 gene polymorphism and the risk of colorectal cancer in a Saudi Arabian population
Authors: M.N. Khabaz1, T. Nedjadi2, M.A. Gari3, J.A. Al-Maghrabi4, H.M. Atta5,M. Bakarman6 and Z.J. Gazzaz7
The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene. Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms the basis of the debate about the impact of the GSTM1 null/present genotype on colorectal carcinoma risk. We tested the potential influence of GSTM1 polymorphisms on the development of co.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017551
- DOI:
- 10.4238/gmr.15017551
Obese gene polymorphism in Pietrain and large white pigs after a divergent selection
Authors: A.C.P. Silveira, R.C. Antunes, J.F. Almeida, T.F. Braga, P.F.A. Freitas, A.S.M. C�©sar and E.C. Guimar�£es
The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by polymerase chain reaction and genotyped by restriction fra.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr511
- DOI:
- 10.4238/vol7-4gmr511
Molecular characterization of an expressed sequence tag representing the cuticle-degrading serine protease gene (PII) from the nematophagous fungus Arthrobotrys oviformis by differential display technology
Authors: A. Nagee, A. Acharya, A. Shete, P.N. Mukhopadhyaya and B.A. Aich
The technology of mRNA-based differential display reverse transcriptase-polymerase chain reaction (DDRT-PCR) was used to detect a 246-bp differentially expressed fragment from the nematophagous fungus Arthrobotrys oviformis when young mycelia were induced with the round worm Haemonchus contortus. The fragment was converted into an expressed sequence tag (.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr487
- DOI:
- 10.4238/vol7-4gmr487
Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer�s disease in the Chinese population: a meta-analysis of case-control studies
Authors: L. Yang, H.-H. Zhou, Y.-F. Ye, X.-W. Fan, Y.-J. Wang and Y. Meng
The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly inves.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.5
- DOI:
- 10.4238/2015.February.6.5
Association of MEF2A gene 3'UTR mutations with coronary artery disease
Authors: X.C. Huang and W. Wang
Association of variants in the myocyte enhancer factor 2A (MEF2A) gene and the risk of coronary artery disease (CAD) has drawn much attention but remains controversial. We hypothesized that the 3'-untranslated region (3'-UTR) of this gene could harbor functionally relevant nucleotide changes. Here, we assessed the association between single nucleotide pol.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.20
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.20
Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis
Authors: B.W. Yu, L.Q. Zhang, X.L. Teng, Y. Zhang, L.B. Zou and H.Y. Ying
Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 Tï¼Â?C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.11
- DOI:
- 10.4238/2015.February.6.11
Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population
Authors: G. g�¼m�¼��-akay, A. r�¼stemo��lu, A. karada�� and A. sunguro��lu
Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to .. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr496
- DOI:
- 10.4238/vol7-4gmr496
Molecular markers in commercial Bombyx mori (Lepidoptera: Bombycidae) hybrids susceptible to multiple nucleopolyhedrovirus
Authors: L.F.C. Ribeiro D.B. Zanatta J.P. Bravo R.M.C. Brancalh�£o M.A. Fernandez
The silkworm Bombyx mori L. is particularly susceptible to virus diseases, especially B. mori nucleopolyhedrovirus (BmNPV). Disease resistance, along with high productivity, are important selection criteria for developing commercial hybrids of B. mori. We used bioassays and molecular markers linked to susceptibility/resistance.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr540
- DOI:
- 10.4238/vol8-1gmr540
G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients
Authors: X.W. Hou, Z.H. Hu, Y. Cui, W. Gao, S.P. Sun and N.F. Wang
Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have n.. Read More»
- Genet. Mol. Res. 10(4):