Polymorphism
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Authors: J.V.M. Martins, D.A. Rodrigues, K.S.F. Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. Morais and K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regu.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039620
- DOI:
- 10.4238/gmr16039620
Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population
Authors: Z. Fang, M. Li, Z. Ma and G. Tu
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, t.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16037446
- DOI:
- 10.4238/gmr16037446
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population
Authors: V.R.Z.B. Pereira, J.M. Wolf, G.Z. Stumm, T.R. Boeira, J. Galvan, D. Simon and V.R. Lunge
Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029565
- DOI:
- 10.4238/gmr16029565
Association between the -77T>C polymorphism in the DNA repair gene XRCC1 and lung cancer risk
Authors: B.B. Sun, J.Z. Wu, Y.G. Li and L.J. Ma
Numerous studies have evaluated the association between the X-ray repair cross-complementing group 1 (XRCC1) DNA repair gene polymorphism -77T>C and lung cancer risk. However, this association is controversial. We used PubMed and Embase to identify 5 case-control studies, which included 2488 lung cancer cases and 2576 controls, for inclusion in a compr.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.17
- DOI:
- 10.4238/2014.December.4.17
Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma
Authors: N.B. Costa, C.T.X. Silva, A.B. Frare, R.E. Silva and K.K.V.O. Moura
The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influence.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.33
- DOI:
- 10.4238/2014.December.4.33
Roles of beta2-adrenergic receptor gene polymorphisms in a Turkish population with obstructive sleep apnea syndrome or obesity
Authors: �°. G�¶k1, �°. ��elebi2, N. H�¼seyino��lu3 and C. ��zic1
We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral b.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.27
- DOI:
- 10.4238/2014.October.20.27
Correlation between the NPPB gene promoter c.-1298 G/T polymorphism site and pulse pressure in the Chinese Han population
Authors: K. Zeng, X.D. Wu, H.D. Cai, Y.G. Gao, G. Li , Q.C. Liu, F. Gao, J.H. Chen and C.Z. Lin
The aim of this study was to investigate the correlation between the natriuretic peptide precursor B (NPPB) gene single nucleotide polymorphism (SNP) c.-1298 G/T and pulse pressure (PP) of the Chinese Han population and the association between genotype and clinical indicators of hypertension. Peripheral blood was collected fro.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.4
- DOI:
- 10.4238/2014.April.29.4
Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever
Authors: F. ��ktem, H. An�±l, R. S�¼tc�¼ and A.E. Kuybulu
Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF... Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.7
- DOI:
- 10.4238/2014.April.29.7
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine
Authors: M. Zhou, Y.J. Ding, Y. Feng, Q.R. Zhang, Y. Xiang and H.Y. Wan
Xeroderma pigmentosum group D (XPD) plays a key role in the repair of DNA and platinum resistance lesions. Cytidine deaminase (CDA) genes determine the velocity of gemcitabine catalysis. This study aimed to investigate the relationship between XPD and CDA genotypes and outcome in non-small lung cancer (NSCLC) patients. We used.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.9
- DOI:
- 10.4238/2014.April.29.9
Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens
Authors: S.K. Zhu, Y.D. Tian, S. Zhang, Q.X. Chen, Q.Y.Wang,R.L. Han and X.T. Kang
Delta-6 fatty acid desaturases are rate-limiting desaturases involved in metabolic processes of fatty acids, and they are encoded by the FADS2 gene. In the current study, an F2 resource population of Gushi chickens crossed with Anak broilers was used to investigate the genetic effects of the chicken FADS2. Two adjacent single .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.11
- DOI:
- 10.4238/2014.April.29.11