Polymorphism
Association between matrix metalloproteinase-3 polymorphism and anterior cruciate ligament ruptures
Authors: S. Malila, P. Yuktanandana, S. Saowaprut, W. Jiamjarasrangsi and S. Honsawek
Anterior cruciate ligament (ACL) ruptures are considered to be the most severe joint injury in sports. However, the precise etiologies of ACL injuries are not fully understood. Recently, the gene encoding the matrix metalloproteinase-3 (MMP-3, stromelysin-1) was shown to be associated with anterior cruciate ligament ruptures. .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.1
- DOI:
- 10.4238/2011.October.31.1
Prevalence of vitamin D receptor gene polymorphism in a Uruguayan population and its relation to type 1 diabetes mellitus
Authors: Mimbacas A, Trujillo J, Gascue C, Javiel G and Cardoso H
Vitamin D has important immuno-modulatory properties and it influences insulin secretion. It acts through a vitamin D receptor (VDR), for which several gene polymorphisms have been described. The Uruguayan population presents several epidemiological characteristics that make it different from that of other counties, including .. Read More»
- Genet. Mol. Res. 6(3):
Effect of CYP2C9*3 mutant variants on meloxicam pharmacokinetics in a healthy Chinese population
Authors: M. Zhang, Y. Yang, G. Zhao, X. Di, L. Xu, N. Jiang, J. Xu and X. Xu
The aim of this study was to investigate the effect of the CYP2C9*3 (CYP2C9 1075 A>C) polymorphism on meloxicam pharmacokinetics in a Chinese population. Twenty-four healthy volunteers were enrolled in this study. The pyrosequencing technique was used to identify polymorphisms of CYP2C9. The concentration of meloxicam in pl.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.13.1
- DOI:
- 10.4238/2014.February.13.1
Association between the epithelial cadherin -160C/A gene polymorphism and diffuse gastric cancer risk: a meta-analysis.
Authors: X.W. Chen, J.X. Sun, Z.N. Wang, P. Gao, Y.X. Song, J.F. Cao, B. Liu and H.M. Xu
Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of rel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.13.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.13.3
Analysis of POU1F1 gene DdeI polymorphism in Chinese goats
Authors: M.J. Li1,2, C.M. Zhang2, X.Y. Lan1, X.T. Fang3, C.Z. Lei1 and H. Chen1
As a member of the POU-domain family, the POU1F1 is a positive regulator for growth hormone, prolactin and thyroid-stimulating hormone b, by binding to target DNA promoters as a dimer in mammals. This study described the polymorphisms at the goat POU1F1-DdeI locus and analyzed the distribution of alleles in 15 indigenous Chinese goat breeds. The PCR-RFLP .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017747
- DOI:
- 10.4238/gmr.15017747
Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis
Authors: S. Yan Y.Z. Li J.W. Zhu C.L. Liu P. Wang Y.L. Liu
We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.26.1
- DOI:
- 10.4238/2012.November.26.1
Association between IL-1�± rs17561 and IL-1�² rs1143634 polymorphisms and periodontitis: a meta-analysis
Authors: W.T. Yin, Y.P. Pan and L. Lin
Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017325
- DOI:
- 10.4238/gmr.15017325
A novel polymorphism of the myogenin gene is associated with body measurement traits in native Chinese breeds
Authors: M. Xue, L.S. Zan, L. Gao and H.B. Wang
Using PCR-SSCP and DNA sequencing technology, we examined the association of single nucleotide polymorphisms (SNPs) in the bovine MyoG gene with body measurement traits in 779 individuals of six native Chinese cattle breeds, namely Luxi, Luxi × Simmental crossbred, Nanyang, Xia’nan, Jiaxian red, and Qinchuan. A nov.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.4.6
- DOI:
- 10.4238/2011.November.4.6
Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population:a meta-analysis
Authors: G.Q. Zhou, H. Meng, J.R. Wang, F.X. Sun, X.J. Wang, R.B. Wang and X.B. Wang
Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.9
- DOI:
- 10.4238/2015.May.11.9
AGPAT6 polymorphism and its association with milk traits of dairy goats
Authors: C. He, C. Wang, Z.H. Chang, B.L. Guo, R. Li, X.P. Yue, X.Y. Lan, H. Chen and C.Z. Lei
As one of the eight members in the 1-acylglycerol-3-phosphate-O-acyltransferase (AGPATs) family, AGPAT6 is a crucial enzyme for the biosynthesis of glycerolipids and triacylglycerol in eukaryotes, as well as catalyzing the conversion from lysophosphatidic acid to phosphatidic acid. AGPAT6 can be considered as a candidate gene .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.4.8
- DOI:
- 10.4238/2011.November.4.8