Polymorphism
Analysis of agouti signaling protein (ASIP) gene polymorphisms and association with coat color in Tibetan sheep (Ovis aries)
Authors: J.L. Han, M. Yang, Y.J. Yue, T.T. Guo, J.B. Liu, C.E. Niu and B.H. Yang
Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.22
- DOI:
- 10.4238/2015.February.6.22
Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study
Authors: B.-L. Shen, Q.-S. Qu, S.-Z. Miao and Y.-X. Zhang
We conducted this case-control study to assess the role of the VEGF -2578C/A, +1612G/A, +936C/T and -634G/C gene polymorphisms in the development of renal cell carcinoma (RCC). A hospital-based case-control study was conducted in a 360 consecutive primary RCC patients and 360 age and gender-matched controls during January 2010 and January 2014. The polyme.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.5
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.5
Transcriptional co-activator PGC-1�± gene is associated with chicken skeletal muscle fiber types..
Authors: J.T. Shu, W.J. Xu, M. Zhang, W.T. Song, Y.J. Shan, C. Song, W.Q. Zhu, X.Y. Zhang and H.F. Li
The peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) is a candidate gene for meat quality traits because of its prominent role in muscle fiber type switching and determination. We investigated the effects of the PGC-1α gene on chicken skeletal muscle fiber type switching and on othe.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.14.19
- DOI:
- 10.4238/2014.February.14.19
Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer
Authors: J. Wang, T. Wang, G.-Y. Yin, L. Yang, Z.-G. Wang and X.-B. Bu
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.6
Lack of an association between -308G>A polymorphism of the TNF-�± gene and liver cirrhosis risk based on a meta-analysis
Authors: D. Chen, J.L. Liu, Y. Liu, J. Zhu and S.W. Wang
TNF-α is a potential proinflammatory cytokine that plays an important role in the pathogenesis of liver cirrhosis. We investigated a possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by conducting a meta-analysis. Publications addressing the association between TNF-α -308G>.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.8.2
- DOI:
- 10.4238/2011.November.8.2
Detection of polymorphisms of the mtDNA control region of Caretta caretta (Testudines: Cheloniidae) by PCR-SSCP
Authors: E.C. Reis R.M. Albano A.C.V. Bondioli L.S. Soares G. L�´bo-Hajdu
Marine turtles are increasingly being threatened worldwide by anthropogenic activities. Better understanding of their life cycle, behavior and population structure is imperative for the design of adequate conservation strategies. The mtDNA control region is a fast-evolving matrilineal marker that has been employed in the study.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr570
- DOI:
- 10.4238/vol8-1gmr570
Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia
Authors: Y. Mu Z. Xu C.I. Contreras J.S. McDaniel K.J. Donly S. Chen
Both BMP2 and BMP4 are involved in tooth development. We examined phenotypes and BMP2 and BMP4 gene variations in two Mexican oligodontia families. Physical and oral examinations and panoramic radiographs were performed on affected and unaffected members in these two families. The affected members lacked six or more teeth. DNA sequencing was performed to .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.25.5
- DOI:
- 10.4238/2012.September.25.5
Validation of associations between ESR1 variants and breast cancer risk in Chinese cohorts
Authors: X. Li, G.Y. Yao, F.X. Li, Y.R. Qiu and X.X. Yang
Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and common genetic variants in the corresponding gene locus have been associated with breast cancer risk in different populations. Here, we analyzed estrogen receptor 1 (ESR1) associations in two hospital-based studies of patients from the south of China. Three single-nucleotide p.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036683
- DOI:
- 10.4238/gmr.15036683
Transcriptional co-activator PGC-1�± gene is associated with chicken skeletal muscle fiber types
Authors: J.T. Shu, W.J. Xu, M. Zhang, W.T. Song, Y.J. Shan, C. Song, W.Q. Zhu, X.Y. Zhang and H.F. Li
The peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) is a candidate gene for meat quality traits because of its prominent role in muscle fiber type switching and determination. We investigated the effects of the PGC-1α gene on chicken skeletal muscle fiber type switching and on othe.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.14.19
- DOI:
- 10.4238/2014.February.14.19
Candidate genes for production traits in Nelore beef cattle
Authors: P.C. Tizioto S.L. Meirelles R.R. Tulio A.N. Rosa M.M. Alencar S.R. Medeiros F. Siqueira G.L.D. Feij�³ L.O.C. Silva R.A.A. Torres J�ºnior L.C.A. Regitano
Meat quality is an important trait for the beef industry. Backfat thickness, ribeye area, and shear force are traits measured late in life, and the investigation of molecular markers associated with these traits can help breeding programs. In cattle, some polymorphisms have been related to production traits. Thus, the purpose of this study was to assess t.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.19.1
- DOI:
- 10.4238/2012.September.19.1