Polymorphism
TNF-�± -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The purpose of this study was to examine whether tumor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted examining the association between TNF-α -308 A/G and -238 A/G polymorphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorph.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.30
- DOI:
- 10.4238/2015.May.11.30
Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population
Authors: M.F. Ying and R. Zhao
We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer. This study included 195 patients who were newly diagnosed with histopathologically confirmed primary pancreatic cancer, and 254 controls were recruited from Sir Run Run Shaw Hospital, between January 2012 and December 2014. Genotyp.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017273
- DOI:
- 10.4238/gmr.15017273
Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China
Authors: M.J. Zhang, L.X. Xing, M. Cui, X. Yang, J.G. Shi, J. Li, K.J. Zhang, Z.J. Zheng, F.C. Zhang, J.L. Li and X.C. Gao1,3
TUSC3 interacts with the protein phosphatase 1 and magnesium ion transport system, which plays an important role in learning and memory. Abnormal conditions of learning and memory are common clinical characteristics of mental retardation (MR). However, the association of TUSC3 genetic polymorphisms with MR remains unknown. A total of 456 DNA samples inclu.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.5
- DOI:
- 10.4238/2015.May.12.5
Glutathione S-transferase pi polymorphism contributes to the treatment outcomes of advanced non-small cell lung cancer patients in a Chinese population
Authors: J.B. Chen, F. Wang, J.J. Wu and M. Cai
We analyzed the association between polymorphisms in three glutathione S-transferase genes (GSTP1, GSTM1, and GSTT1) and the treatment outcome for advanced non-small cell lung cancer (NSCLC). We recruited 284 NSCLC patients at advanced stage from Department of Radiotherapy in Peace Hospital Attached to Changzhi Medical College between May 2009 and May 201.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037498
- DOI:
- 10.4238/gmr.15037498
MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients
Authors: F. Mahjoubi, S. Akbari, M. Montazeri and F. Moshyri
One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance prot.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr482
- DOI:
- 10.4238/vol7-4gmr482
Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy
Authors: J.J. Jiang X. Wu P. Zhou W.Z. Yu L.Z. Huang X.X. Li
We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ra.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.17.1
- DOI:
- 10.4238/2012.December.17.1
Association between Toll-like receptor 9 gene polymorphisms and risk of bacterial meningitis in a Chinese population
Authors: X.H. Wang, H.P. Shi and F.J. Li
We determined whether two common single nucleotide polymorphisms (SNPs) in the Toll-like receptor 9 gene (TLR9) (TLR9+2848 rs352140 and TLR9-1237 rs5743836) influenced susceptibility to bacterial meningitis in a Chinese population. The study comprised 126 patients with bacterial meningitis and 252 control subjects, all of whom were recruited from the Tube.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037641
- DOI:
- 10.4238/gmr.15037641
Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis
Authors: H.Y. Cao, S. Wang, Z.Y. Zhang and J.Y. Lou
The TP53 5'-untranslated region flanking the gene WRAP53 (also known as WDR79 and TCAB1) has been hypothesized to be associated with cancer risk due to its critical function in regulating p53 levels. In this review, we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies, compris.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037976
- DOI:
- 10.4238/gmr.15037976
Association between the Val34Leu polymorphism in blood coagulation factor XIII-A and intracerebral hemorrhage: a meta-analysis
Authors: X. Ye and B. Ye
Although the Val34Leu polymorphism in blood coagulation factor XIII-A (FXIII-A) has been implicated in the pathogenesis of intracerebral hemorrhage (ICH), the results of research conducted thus far have been inconclusive. In this meta-analysis, we have assessed the association between the FXIII-A Val34Leu polymorphism and ICH risk. Published reports perta.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038327
- DOI:
- 10.4238/gmr.15038327
Development of novel microsatellite markers in the Korean rockfish Sebastes schlegeli
Authors: H.-T. Ma, C.-F. Jia, J.-M. Yang, F. Wang, R. Xue, C.-H. Han and H.-B. Jiang
The Korean rockfish Sebastes schlegeli is a valuable recreational and commercial fish in China, and is cultured in land-based tanks and net cages. Fifteen microsatellite markers were developed for this species, and their polymorphisms were examined in a population. The allele number of the 15 markers ranged from 2 to 13, with an average of 5.933 per locus.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.12
- DOI:
- 10.4238/2015.May.12.12