Polymorphism
Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients
Authors: M. Katar, A.F. Ozugurlu, H. Ozyurt and I. Benli
Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present s.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.4
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.4
Tumor necrosis factor receptor-II nt587 polymorphism in Chinese Han patients with ankylosing spondylitis
Authors: X. Li, M. Wang, R. Ma, T. Zhang, J. Liu, J.W. Chen and W. Peng
We aimed to explore the association between the onset of ankylosing spondylitis (AS) and nt587 polymorphisms of the tumor necrosis factor receptor II (TNFRII) gene in the Han population of Hunan Province, China. Correlation analysis was performed in a case-control study involving 100 AS cases and 100 healthy controls. The nt58.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.12
- DOI:
- 10.4238/2014.July.7.12
Association between the interleukin 4 gene -590C>T promoter polymorphism and asthma in Xinjiang Uighur children
Authors: J.H. Zhang, G.H. Zhou, T.T. Wei and Z.S. Chang
We investigated the association between the interleukin 4 gene (IL-4) -590C>T polymorphism and forced expiratory volume in one second (FEV1) values, immunoglobulin E (IgE) levels, and susceptibility to asthma in Uighur children. IL-4 -590C>T frequencies were analyzed in 38 bronchial asthmatic patients and 35 non-asthmatic controls. Polymerase chain .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038363
- DOI:
- 10.4238/gmr.15038363
Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis
Authors: Y. Zhao,H.R. He, M.Y. Wang, X.D. Ren, L. Zhang, Y.L. Dongand J. Lu
Cyclin D1 (CCND1) is a key protein involved in cellcycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.7
- DOI:
- 10.4238/2015.May.18.7
Association of NF-�ºB1 gene polymorphisms with coronary artery disease in a Han Chinese population
Authors: X.L. Guo, X.C. Liu, G.B. Su, C.Y. Zhou and Q.T. Cui
Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038072
- DOI:
- 10.4238/gmr.15038072
The 341C/T polymorphism in the GSTP1 gene and lung cancer risk: a meta-analysis
Authors: F. Yan, R. Wang and L. Geng
Numerous studies have evaluated the association between the 341C/T polymorphism in glutathione S-transferase P1 (GSTP1) and lung cancer risk. However, there are conflicting results from previous studies. To derive a more precise estimation of the association, we conducted this meta-analysis. A comprehensive search was conducted to identify the eligible st.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038172
- DOI:
- 10.4238/gmr.15038172
CYP2E1 PstI polymorphism increases cervical neoplasia risk: a meta-analysis
Authors: X. Wang and Y. He
Cytochrome P4502E1 (CYP2E1) is a key enzyme in the metabolic activation of many carcinogens, but the roles of CYP2E1 polymorphisms in cervical neoplasia (CN) are inconclusive. Published case-control cohort studies from the Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios with .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.11
- DOI:
- 10.4238/2015.May.18.11
Association of the TNF-�± +489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.12
- DOI:
- 10.4238/2015.May.18.12
Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania
Authors: E. Marku, P.E. Maltese, M. Koni, N. Capodicasa, I.S. Qendro, E. Rigoni, S. Cecchin and M. Bertelli
Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.13
- DOI:
- 10.4238/2015.May.18.13
Functional polymorphisms in microRNAs and susceptibility to liver cancer: a meta-analysis and meta-regression
Authors: B.S. Wang, Z. Liu, W.X. Xu and S.L. Sun
MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.22
- DOI:
- 10.4238/2014.July.24.22