Polymorphism
Association of dietary intake of folate and MTHFR genotype with breast cancer risk
Authors: Z.G. Wang, W. Cui, L.F. Yang, Y.Q. Zhu and W.H. Wei
We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.24.24
- DOI:
- 10.4238/2014.July.24.24
Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome
Authors: P.E. Maltese, L. Venturini, E. Poplavskaya, M. Bertelli, S. Cecchin, M. Granato, S.Y. Nikulina, A. Salmina, N. Aksyutina, E. Capelli, G. Ricevuti and L. Lorusso
Chronic fatigue syndrome (CFS) is a disease that can seriously impair one’s quality of life; patients complain of excessive fatigue and myalgia following physical exertion. This disease may be associated with abnormalities in genes affecting exercise tolerance and physical performance. Adenosine monophosphate deaminase(AMPD1), carnitine palmitoyltra.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038717
- DOI:
- 10.4238/gmr.15038717
Association study between single nucleotide polymorphisms in leptin and growth traits in Cyprinus carpio var. Jian
Authors: Y. Tang, H. Li, J. Li, F. Yu and J. Yu
Leptin is a hormone that affects the regulation of body weight, energy expenditure, fat metabolism, food intake, and appetite. In this study, we cloned the jlLEP-A1 and jlLEP-A2 genes in Jian carp (Cyprinus carpio var. Jian) and performed an association analysis between identified polymorphisms and growth traits. Three polymorphisms in exons of jlLEP-A1 (.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037635
- DOI:
- 10.4238/gmr.15037635
Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population
Authors: W.M. Zhao, P. Shayimu, L. Liu, F. Fang and X.L. Huang
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospital-based case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 20.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037864
- DOI:
- 10.4238/gmr.15037864
Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study
Authors: H.Y. Yang, S.Y. Chuang, W.H. Fang, G.S. Huang, C.C. Wang, Y.Y. Huang, M.Y. Chu, C. Lin, W. Su, C.Y. Chen, Y.T. Yang and S.L. Su
Recent studies have revealed that the inflammatory process plays a role in the pathogenesis of osteoarthritis (OA). The S100 family and receptor for advanced glycation end products (RAGE)participate in regulating inflammation, even in the production of matrix metalloproteinases (MMPs). MMP-1 degrades cartilage, which may result in OA development. Moreover.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.25.3
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.3
Identification of single nucleotide polymorphisms in the ASB15 gene and their associations with chicken growth and carcass traits
Authors: Y.C. Wang, R.R. Jiang, X.T. Kang, Z.J. Li, R.L. Han, J. Geng,J.X. Fu, J.F. Wang and J.P. Wu
ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs3157592.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.25.5
- DOI:
- http://dx.doi.org/10.4238/2015.September.25.5
Genome-wide association with residual body weight gain in Bos indicus cattle
Authors: M.H.A. Santana, R.C. Gomes, Y.T. Utsunomiya, H.H.R. Neves, F.J. Novais, M.N. Bonin, H. Fukumasu, J.F. Garcia, P.A. Alexandre, G.A. Oliveira Junior, L.L. Coutinho and J.B.S. Ferraz
Weight gain is a key performance trait for beef cattle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on performance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and genomic regions associated with residual bo.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.14
- DOI:
- 10.4238/2015.May.18.14
Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis
Authors: Y. Liu, M.C. Yu, A.Q. Zhang, Y.B. Wang, K. Jiang and J.H. Dong
We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.1
- DOI:
- 10.4238/2015.February.13.1
1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients
Authors: S.A. Gutierrez-Rubio, A. Quintero-Ramos, A. Dur�¡n-C�¡rdenas,R.A. Franco-Topete, J.M. Castro-Cervantes, A. Oceguera-Villanueva, L.M. Jim�©nez-P�©rez, L.M.A. Balderas-Pe�±a, G. Morgan-Villela,A. Del-Toro-Arreola and A. Daneri-Navarro
MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association bet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.3
- DOI:
- 10.4238/2015.February.13.3
Characterization and phylogenetic analysis of the swine leukocyte antigen 3 gene from Korean native pigs
Authors: H.Y. Chung, Y.C. Choi and H.N. Park
We investigated the phylogenetic relationships between pig breeds, compared the genetic similarity between humans and pigs, and provided basic genetic information on Korean native pigs (KNPs), using genetic variants of the swine leukocyte antigen 3 (SLA- 3) gene. Primers were based on sequences from GenBank (accession Nos. AF464010 and AF464009). Polymera.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.19
- DOI:
- 10.4238/2015.May.18.19