Polymorphism
Lack of association between a common polymorphism of the endothelial lipasegene and early-onset coronary artery disease in a Chinese Han population
Authors: G.J. Cai, G.P. He, Z.Y. Huang, and C.P. Qi
A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.7
- DOI:
- 10.4238/2014.February.20.7
Genetic diversity and phylogenetic relationship among Tunisian cactus species (Opuntia) as revealed by random amplified microsatellite polymorphism markers
Authors: M. Bendhifi Zarroug, G. Baraket, L. Zourgui, S. Souid and A. Salhi Hannachi
Opuntia ficus indica is one of the most economically important species in the Cactaceae family. Increased interest in this crop stems from its potential contribution to agricultural diversification, application in the exploitation of marginal lands, and utility as additional income sources for farmers. In Tunisia, O. ficus indica has been affected by dras.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.21
- DOI:
- 10.4238/2015.February.13.21
Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China
Authors: H.L. Wei, J.R. Pei, C.X. Jiang, L.W. Zhou, T. Lan, M. Liu and T. Wang
Keshan disease (KD) is an endemic cardiomyopathy associated with selenium deficiency. Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism,.. Read More»
- Genet. Mol. Res. 10(4):
Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study
Authors: A.L. Miranda-Vilela, A.K. Akimoto, P.C.Z. Alves, L.B. Ferreira, G.S. Lordelo, J.G.M. Melo, C.K. Grisolia, S.F. Oliveira and M.N. Klautau-Guimar�£es
Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigate.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr973
- DOI:
- 10.4238/vol9-4gmr973
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients
Authors: B. Sun, J. Li, M. Dong, L. Yang, C. Wu, L. Zhu and Y.L. Cong
We investigated the correlation between genetic polymorphisms of cytochrome P450 enzyme genes and the outcome of clopidogrel treatment in 118 coronary disease patients after percutaneous coronary intervention at the Chinese PLA General Hospital. Patients were divided into an ischemia event relapse group (IERG) and a non-IERG group (NIERG) based on relapse.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.22
- DOI:
- 10.4238/2015.February.13.22
Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures
Authors: M. Yildiz, M. Karkucak, T. Yakut, O. Gorukmez and A. Ozmen
One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of t.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr887
- DOI:
- 10.4238/vol9-4gmr887
Genetic characterization of heat tolerant tomato (Solanum lycopersicon) genotypes by SRAP and RAPD markers
Authors: N. Comlekcioglu, O. Simsek, M. Boncuk and Y. Aka-Kacar
We employed RAPD and sequence-related amplified polymorphism (SRAP) markers to evaluate polymorphisms in 15 tomato (Solanum lycopersicon) genotypes that were obtained from a tomato breeding program. Four local tomato genotypes selected from the Sanliurfa province (Southeastern Anatolia Region of Turkey), 10 heat-tolerant tomat.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr876
- DOI:
- 10.4238/vol9-4gmr876
Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules
Authors: A.A.S. Reis, D.M. Silva, M.P. Curado and A.D. da Cruz
Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individ.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr807
- DOI:
- 10.4238/vol9-4gmr807
Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population
Authors: Q. Qadri, A.S. Sameer, Z.A. Shah, A. Hamid, S. Alam, S. Manzoor and M.A. Siddiqi
Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investig.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.6.4
- DOI:
- 10.4238/2011.December.6.4
Effect of p53 gene polymorphism on functions of prostate cancer cells
Authors: N. Chi, Z.Z. Yun, Z.H. Tan, X.Z. Li, B.T.B.G. Chen, J. Liu, L.B. Xu, K.W. Ma, S.X. Li, J.F. Liu and C.X. Liu
Prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcDNA3.1-p53 (V/V), mutant type pcDNA3.1- p53 (G/G)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. Empty plasmids containing wild-type pcDNA3.1-p53 (V/V) and mutant type pcDNA3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.3
- DOI:
- 10.4238/2015.October.2.3