Polymorphism
Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis
Authors: H. Yuan, Y.M. Niu, R.X. Wang, H.Z. Li and N. Chen
Several studies have investigated the association between Lys751Gln polymorphism in the xeroderma pigmentosum group D (XPD) gene and risk of head and neck cancer; however, the published results are conflicting. We conducted a meta-analysis that comprised 15 published case-control studies examining the association of head and n.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.22.6
- DOI:
- 10.4238/2011.November.22.6
Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China
Authors: H.P. Xu, X.M. He, M.X. Fang, Y.S. Hu, X.Z. Jia, Q.H. Nie and X.Q. Zhang
The dopamine D2 receptor (DRD2) is a crucial mediator for normal physiological processes. We cloned the pig DRD2 gene, investigated its distribution in tissues and identified polymorphisms by RT-PCR, quantitative real-time PCR and direct sequencing. Two Yorkshire pigs from Guangdong Academy of Agricultural Sciences (Guangzhou,.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.6
- DOI:
- 10.4238/2011.December.5.6
GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas
Authors: A.C. Cust�³dio, L.O. Almeida, G.R. Pinto, M.J. Santos, J.R.W. Almeida, C.A. Clara, J.A. Rey and C. Casartelli
Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr971
- DOI:
- 10.4238/vol9-4gmr971
Genetic polymorphism, molecular characterization and relatedness of Macrobrachium species (Palaemonidae) based on RAPD-PCR
Authors: A.L. Guerra, A.V.B. Lima, F.G. Taddei and L. Castiglioni
The prawn genus Macrobrachium belongs to the family Palaemonidae. Its species are widely distributed in lakes, reservoirs, floodplains, and rivers in tropical and subtropical regions of South America. Globally, the genus Macrobrachium includes nearly 210 known species, many of which have economic and ecological importance. We .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr935
- DOI:
- 10.4238/vol9-4gmr935
Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women
Authors: Z.S. ��zkan, D. Deveci, E. ��nalan Etem and H. Y�¼ce
We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women wi.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr922
- DOI:
- 10.4238/vol9-4gmr922
IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis
Authors: X.B. Bao, Z. Ma, J.B. Gu, X.Q. Wang, H.G. Li and W.Y. Wang
We conducted a case-control study to clarify the associations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634 C/G (rs1800796), IL-8 -251T/A (rs407.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.6
- DOI:
- 10.4238/2015.February.20.6
An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population
Authors: T. Tencomnao and J. Wongpiyabovorn
The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr920
- DOI:
- 10.4238/vol9-4gmr920
Analysis of genetic diversity of the heat shock protein 70 gene on the basis of abundant sequence polymorphisms in chicken breeds
Authors: J.K. Gan, L.Y. Jiang, L.N. Kong, X.Q. Zhang and Q.B. Luo
This study was designed to detect the sequence variation of the chicken heat shock protein 70 (HSP70) gene. A total of 102 individuals from 8 native Chinese breeds together with Dwarf White Chicken and Red Junglefowl were used to detect sequence variations. The coding regions of the chicken HSP70 gene from 102 individuals were cloned and sequenced. Thirty.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.1
- DOI:
- 10.4238/2015.March.6.1
Prevalence of CCR5-Ã?Â?32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil
Authors: H. Ferreira-Fernandes, A.C.C. Santos, F.J.N. Motta, R. Canalle, F.K.N. Yoshioka, R.R. Burbano, J.A. Rey, B.B. da Silva and G.R. Pinto
Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-Δ32 and CCR2-V64I are related to human immunodeficiency virus infection resis.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.4
- DOI:
- 10.4238/2015.October.2.4
Association between the C804A polymorphism in the TGF-�² gene and the risk of myocardial infarction: a meta-analysis
Authors: D.W. Suo, Q. Hu, J. Chen, Q.H. Sun and H. Guo
Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evalu.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.4
- DOI:
- 10.4238/2015.March.6.4