Polymorphism
Androgen receptor gene CAG repeat polymorphism and risk of isolated hypospadias: results from a meta-analysis
Authors: G. Huang, W. Shan, L. Zeng and L. Huang
Studies investigating the association between the CAG repeat polymorphism and the risk of isolated hypospadias have reported conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, CNKI, and Wanfang databases. Weighted mean difference and.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.5
- DOI:
- 10.4238/2015.March.6.5
Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever
Authors: A. R�¼stemoglu, G. Gumus-Akay, S. Yigit and T. Tasliyurt
The multidrug resistance (MDR1) gene encodes a P-glycoprotein that plays a key role in drug bioavailability and response to drugs in different human populations. More than 50 SNPs have been described for the MDR1 gene. Familial Mediterranean fever (FMF) is considered an autosomal recessive hereditary disease, associated with a.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.7
- DOI:
- 10.4238/2011.December.14.7
Cloning, partial sequence, and single-nucleotide polymorphism of the ryanodine receptor gene of the Pacific white shrimp Litopenaeus vannamei (Penaeidae)
Authors: X.H. Chen, D.G. Zeng and N. Ma
Ryanodine receptor/calcium release channel is a large protein that plays an essential role in muscle contraction; mutations in the ryanodine receptor gene affect sensitivity to stress. As a first step towards investigating the relationship between the ryanodine receptor and shrimp cramped muscle syndrome, we cloned, partially .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr976
- DOI:
- 10.4238/vol9-4gmr976
Association of CYP2C19*3 gene polymorphism with breast cancer in Chinese women
Authors: C.Q. Gan, X.Y. Wang, Y.D. Cao, W.X. Ye, H. Liu and Y.Y. Sun
Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese H.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.3
- DOI:
- 10.4238/2011.December.5.3
Transcriptional analysis of the porcine TTID gene and association of different TTID genotypes with carcass traits
Authors: J. Wang, Y.-P. Feng, B. Zuo, Y.-Z. Xiong and C.-Y. Deng
The titin immunoglobulin domain (TTID) protein localizes to the Z line in muscle and binds to alpha-actinin and gamma-filamin. It plays an indispensable role in stabilizing and anchoring of thin filaments. In this study, the 5'-regulatory region of the porcine TTID gene was analyzed with bioinformatic methods. Another objectiv.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.4
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.4
Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy
Authors: C.-H. Hsieh, D. Pei, Y.-J. Hung and F.-C. Hsiao
Retinoid-X receptor (RXR) is one of the members of the nuclear hormone receptor superfamily. It forms heterodimers with many nuclear receptors, such as the peroxisome proliferative-activated receptor, which has been proposed to be involved in diabetic complications, including retinopathy. A recent study revealed that RXR-alpha.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.4
- DOI:
- 10.4238/2011.December.5.4
�²3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects
Authors: V.A. Genelhu, E.A. Francischetti, S.F.P. Duarte, B.M.J. Celoria, R.C. Oliveira, P.H. Cabello and M.M.G. Pimentel
We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr819
- DOI:
- 10.4238/vol9-3gmr819
+294T/C polymorphism in the PPAR-�´ gene is associated with risk of coronary artery disease in normolipidemic Tunisians
Authors: I. Jguirim-Souissi, A. Jelassi, Y. Hrira, M. Najah, A. Slimani, F. Addad, M. Hassine, K.B. Hamda, F. Maatouk, M. Rouis and M.N. Slimane
Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr831
- DOI:
- 10.4238/vol9-3gmr831
Association of the PPAR�³2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia
Authors: L. Gao*, L. Wang*, H. Yun, L. Su and X. Su
In order to determine whether Pro12Ala polymorphism of the peroxisome proliferator-activated receptor g2 (PPARg2) gene contributes to susceptibility to primary hypertension and metabolic lipid disorders, 482 unrelated subjects from Inner Mongolia were studied, including 137 healthy normotensive (controls) and 345 hypertensive .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr833
- DOI:
- 10.4238/vol9-3gmr833
Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population
Authors: S.F. Tee, T.J. Chow, P.Y. Tang and H.C. Loh
The serotoninergic system has been implicated in the etiology of schizophrenia and other behavioral disorders. Association studies have focused on the tryptophan hydroxylase 2 gene (TPH2) and the 5-hydroxytryptamine receptor 2A gene (5-HTR2A). We genotyped two single-nucleotide polymorphisms, A1438G of 5-HTR2A and intronic rs1.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr789
- DOI:
- 10.4238/vol9-3gmr789