Polymorphism
Genomic structure, polymorphism and expression analysis of growth hormone-releasing hormone and pituitary adenylate cyclase activating polypeptide genes in the half-smooth tongue sole (Cynoglossus semilaevis)
Authors: Q. Ma, S.F. Liu, Z.M. Zhuang, L. Lin, Z.Z. Sun, C.L. Liu, Y.Q. Su and Q.S. Tang
Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase activating polypeptide (PACAP) regulate development and somatic growth in teleosts; they may be associated with sexual growth dimorphism in the half-smooth tongue sole (Cynoglossus semilaevis). We found that the full-length GHRH and PACAP gene sequences ob.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.1
- DOI:
- 10.4238/2011.December.12.1
Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma
Authors: M.J. Wang, Y. Zhu, X.J. Guo and Z.Z. Tian
We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.17
Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia
Authors: X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cho.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.2
- DOI:
- 10.4238/2011.December.12.2
No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population
Authors: L.P. Sun*, X.L. Ma*, H.X. Liu, Y.S. Wang and X.F. Li
Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr914
- DOI:
- 10.4238/vol9-3gmr914
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies
Authors: Y. Zhao, J. Liang, J.G. Qi, N. Yang, G. Wu, Y.L. Lin, J.Y. Cao, Q. Wang and Q.C. Wang
Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.18
- DOI:
- 10.4238/2015.July.3.18
Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region
Authors: W.H. Huang, Z.X. Ma, Z.Y. Xu, Y.Z. Xiong and B. Zuo
Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and HMGA1 genes, we.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.2
- DOI:
- 10.4238/2011.December.14.2
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls
Authors: Y. Zhao, Z.L. Gui, S. Liao, F. Gao, Y.Z. Ge and R.P. Jia
Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that in.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.7
- DOI:
- 10.4238/2014.July.25.7
Genetic polymorphism in sex hormone metabolism and prostate cancer risk
Authors: E. Ersekerci, M. Sofikerim, S. Taheri, A. Demirtas and F. Halis
We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.8
- DOI:
- 10.4238/2015.July.3.8
Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis
Authors: D. Wu, Y. Wu, J.L. Liu3, B. Wang and X.D. Zhang
Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 p.. Read More»
- Genet. Mol. Res. 10(4):
Identification of complete linkage disequilibrium in the DSG4 gene and its association with wool length and crimp in Chinese indigenous sheep
Authors: Y.H. Ling, H. Xiang, G. Zhang, J.P. Ding, Z.J. Zhang, Y.H. Zhang, J.L. Han, Y.H. Ma and X.R. Zhang
The desmoglein 4 (DSG4) gene is a potential candidate in the search for genes that may affect wool traits, because of its function. This study aimed to screen for polymorphisms in partial exon 16 and 3êÂ?Â?UTR of the sheep desmoglein 4 DSG4 gene, and to test its possible association with wool length.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.17
- DOI:
- 10.4238/2014.July.25.17