Polymorphism
Lack of association between MD-2 promoter gene variants and tuberculosis
Authors: Y. Xue, Z.Q. Zhao, D. Hong, M.Y. Zhao, Y.X. Zhang, H.J. Wang, Y. Wang and J.C. Li
Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tub.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr771
- DOI:
- 10.4238/vol9-3gmr771
Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population
Authors: W.Q. Wu, L.S. Zhang, S.P. Liao, X.L. Lin, J. Zeng and D. Du
Laryngeal cancer is the major malignant tumor affecting the upper respiratory tract. Previous studies have reported on the association between XRCC1 genetic polymorphisms and risk of laryngeal cancer, but with conflicting results. In this study, we attempted to assess the association between XRCC1 Arg194Trp, Arg280His and Arg3.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048525
- DOI:
- 10.4238/gmr.15048525
Predictive value of vascular endothelial growth factor polymorphisms on the risk of renal cell carcinomas
Authors: W. Xian, H. Zheng and W.J. Wu
We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymorphisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population included 266 RCC patients who were newly diagnosed and histologically confirmed to have RCC as well as 532 cancer-free.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.8
- DOI:
- 10.4238/2015.July.13.8
Identification of 15 novel polymorphic microsatellite loci in pearl oyster (Pinctada fucata)
Authors: S.G. Fan, J.X. Wang, D.L. Zhang, Y.H. Guo and D.H. Yu
The pearl oyster Pinctada fucata is a commercially important marine shellfish. As a result, genetic improvement and selective-breeding program have been conducted for this species. Polymorphic microsatellites are effective molecular markers to investigate molecular marker-assisted selection and genetic variance. In this study,.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048655
- DOI:
- 10.4238/gmr.15048655
A multiplex panel of short-amplicon insertion-deletion DNA polymorphisms for forensic analysis
Authors: V.R.D. Santos, H.B. Pena and S.D.J. Pena
We have previously developed a panel of 40 insertion-deletion (INDEL) human DNA polymorphisms that was proven to adequately cover the span of global human genetic diversity. The panel was found to have very low matching probabilities with respect to both the global and Brazilian populations. To optimize the panel for application with degraded DNA samples,.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.2
Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population
Authors: W.F. Xia, X.P. Ma, X.R. Li, H. Dong and J.L. Yi
XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influ.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.3
Isolation and characterization of polymorphic microsatellite loci for Pachycrepoideus vindemmiae (Rondani) (Hymenoptera: Pteromalidae)
Authors: W. Chen, L. Fang, J.L. Liu, Z. He and H.Y. Hu
The parasitoid wasp Pachycrepoideus vindemmiae (Rondani) is a common pupal parasitoid of many fly pests that is distributed worldwide. This organism can be used for biological control in orchards or livestock farms. Identifying polymorphic microsatellite loci would be useful for analyzing the population genetic structure of the parasitoid. In the current .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.7
- DOI:
- 10.4238/2015.March.13.7
EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population
Authors: J.H. Torres-Jasso, M.E. MarÃ?Ân, E. Santiago-Luna, J.C. Leoner,J. Torres, M.T. MagaÃ?±a-Torres, F.J. Perea, B. Ibarra and J.Y. SÃ?¡nchez-LÃ?³pez
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.8
- DOI:
- 10.4238/2015.March.13.8
Association between PARK16 gene polymorphisms and susceptibility of Parkinson�s disease in a Chinese population
Authors: H. Xia, Q. Luo, X.X. Li and X.L. Yang
Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson’s disease (PD) patients. Few loci have been verified in different European and Asian populations. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with suscep.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.7
Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population
Authors: A.N. Zhu, X.X. Yang, M.Y. Sun, Z.X. Zhang and M. Li1,
We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom MassA.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.9
- DOI:
- 10.4238/2015.March.13.9