Polymorphism
The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis
Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, M. Taheri, G.R. Bardestani, Z. Zakeri, D.M. Kordi-Tamandani and S. Ghavami
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subje.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr893
- DOI:
- 10.4238/vol9-3gmr893
IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows
Authors: E. Bonakdar, H.R. Rahmani, M.A. Edriss and B.E. Sayed Tabatabaei
We estimated the allele and genotype frequencies of IGF-I/SnaBI gene polymorphism and the concentration of this protein in Holstein dairy cows. We also examined the association with milk yield (305-day milk yield) and milk components (fat and protein percentage, and 305-day milk protein and fat yield). Blood IGF-I levels were .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr874
- DOI:
- 10.4238/vol9-3gmr874
Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus
Authors: Q. Li, Z.R. Qiao, D.B. Liu, J.T. Zeng, J. Zhang, Y. Bo, H.Y. Zu, Q. Hu, X. Wu and S.S. Dong
In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid decarboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untran.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.10
�Ovar-Mhc� - ovine major histocompatibility complex: structure and gene polymorphisms
Authors: V.S.R. Dukkipati, H.T. Blair, D.J. Garrick and A. Murray
The major histocompatibility complex (MHC) in sheep, Ovar-Mhc, is poorly characterised, when compared to other domestic animals. However, its basic structure is similar to that of other mammals, comprising class I, II and III regions. Currently, there is evidence for the existence of four class I loci. The class II region is b.. Read More»
- Genet. Mol. Res. 5(4):
Germline HVR-II mitochondrial polymorphisms associated with breast cancer in Tunisian women
Authors: B. Yacoubi Loueslati, W. Troudi, L. Cherni, K.B. Rhomdhane and L. Mota-Vieira
A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr778
- DOI:
- 10.4238/vol9-3gmr778
Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population
Authors: Y.Z. Dong, Y.X. Huang and T. Lu
In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the con.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.18
- DOI:
- 10.4238/2015.March.13.18
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle
Authors: H.Y. Chung, Y.J. Choi, H.N. Park and M.E. Davis
In this study, we investigated the associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Polymerase chain reaction primers were based on GenBank accession No. AF404761 and amplified approximately 533-bp segments. Newly identified sequences were subm.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.13
Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma
Authors: D. Li, J.J. Peng, Y. Tan, T. Chen, D. Wei, M. Du and T. Zhang
We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were ge.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.2
- DOI:
- 10.4238/2015.March.20.2
Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis
Authors: W. Zhang, L.C. Zhang, H. Chen, P.F. Tang and L.H. Zhang
We conducted a case-control study to assess the relationship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with os.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.10
- DOI:
- 10.4238/2015.July.13.10
Description of electrophoretic and chromatographic hemoglobin profile of Rhinoclemmys punctularia
Authors: Bonini-Domingos CR, Silva MB, Romero RM, Zamaro PJA, Ondei LS, Zago CES, Moreira SB and Salgado CG
Studies of the hemoglobin pattern in Brazilian reptiles are important for determining ecological and phylogenetic relationships, but they are scarce. Peripheral blood samples were obtained from 7 males and 18 females of Rhinoclemmys punctularia. The hematological profile was based on the total hemoglobin and hematocrit values... Read More»
- Genet. Mol. Res. 6(2):