Polymorphism

Transcription factor 7-like 2 polymorphisms and diabetic retinopathy: a systematic review

Authors: P. Sudchada and K. Scarpace

The global prevalence of type 2 diabetes mellitus (T2DM) has increased, as well as complications including diabetic retinopathy. Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated with T2DM, with the strongest association attributed to the single-nucleotide polymorphism rs7903146. In this rev.. Read More»

Genet. Mol. Res. 13(3):

2014.August.7.1

DOI:

10.4238/2014.August.7.1

Assessment of genetic diversity and relationships among wild and cultivated Tunisian plums (Prunus spp) using random amplified microsatellite polymorphism markers

Authors: H. Ben Tamarzizt, S. Ben Mustapha, G. Baraket, D. Abdallah and A. Salhi-Hannachi

Genet. Mol. Res. 14(1):

2015.March.20.4

DOI:

10.4238/2015.March.20.4

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China

Authors: Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyz.. Read More»

Genet. Mol. Res. 9(3):

vol9-3gmr938

DOI:

10.4238/vol9-3gmr938

Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm

Authors: X.T. Sima, J.G. Xu, J. Li and C. You

Vascular inflammation has been shown to be involved in the pathogenesis of intracranial aneurysms (IA). MiRNAs are key molecules that participate in the regulation of many important biological processes including inflammation. Studies on the hsa-miR-146a rs2910164 polymorphism and its association with different inflammatory related diseases have engendere.. Read More»

Genet. Mol. Res. 14(3):

2015.July.13.13

DOI:

10.4238/2015.July.13.13

Interleukin-1B-31 gene polymorphism in Hakka gastric cancer patients in Guangdong, China

Authors: B. Qiu, H.-Y. Zou, Y.-H. Yang and C.-F. Lai

The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization.. Read More»

Genet. Mol. Res. 13(3):

2014.August.7.2

DOI:

10.4238/2014.August.7.2

Optimization of SCoT-PCR reaction system in Dactylis glomerata by orthogonal design

Authors: B. Zeng, X. Huang, L.K. Huang, J. Zhang, H.D. Yan, D. Luo, H. Liang and Y. Yuan

The effects of 5 factors (template DNA, Mg2+, dNTPs, Taq DNA polymerase, and primer) on the polymerase chain reaction (PCR) were investigated to optimize the start codon targeted polymorphism (SCoT)-PCR system of Dactylis glomerata L., using an orthogonal design L16 (45). A suitable SCoT-PCR system for D. glomerata was established; the 20 μL reaction v.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.15

DOI:

http://dx.doi.org/10.4238/2015.April.10.15

Functional characterization of genetic variants in the porcine TLR3 gene

Authors: L. Wang, Y.C. Chen, D.J. Zhang, H.T. Li, D. Liu and X.Q. Yang

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA, which is a molecular signature of viruses, and plays a pivotal role in host defense against viral invasion. Polymorphisms in the human TLR3 gene have been shown to affect the receptor function and to be associated with a variety of diseases, suggesting correlations be.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.28.7

DOI:

http://dx.doi.org/10.4238/2014.February.28.7

Polymorphic microsatellite loci developed from the Hong Kong oyster (Crassostrea hongkongensis)

Authors: H.T. Ma, S. Xiao, Y. Zhang, X.M. Li, J. Li and Z.N. Yu

Forty polymorphic microsatellite loci were developed from Crassostrea hongkongensis using an enriched partial genomic library with magnetic beads. The polymorphism of these loci was assessed in 30 individuals from a wild population. The allele number of the polymorphic markers ranged from 2 to 13, with an average of 5.8 per lo.. Read More»

Genet. Mol. Res. 15(4):

gmr.15048676

DOI:

10.4238/gmr.15048676

Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene

Authors: Rincon G, Young AE, Bannasch DL and Medrano JF

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and anal.. Read More»

Genet. Mol. Res. 6(1):

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

Authors: L.L. Chen, Y. Shen, J.B. Zhang, S. Wang, T. Jiang, M.Q. Zheng, Z.J. Zheng and C.X. Chen

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism i.. Read More»

Genet. Mol. Res. 15(4):

gmr.15048723

DOI:

10.4238/gmr.15048723