Polymorphism
Personalized diagnosis by cached solutions with hypertension as a study model
Authors: P.C. Carvalho, S.S. Freitas, A.B. Lima, M. Barros, I. Bittencourt, W. Degrave, I. Cordovil, R. Fonseca, M.G.C. Carvalho, R.S. Moura Neto and P.H. Cabello
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of .. Read More»
- Genet. Mol. Res. 5(4):
Molecular thrombophilic profile in Mexican patients with idiopathic recurrent pregnancy loss
Authors: J.J. L?³pez-Jim?©nez, ?. Porras-Dorantes, C.I. Ju?¡rez-V?¡zquez,J.E. Garc?a-Ortiz, C.A. Fuentes-Ch?¡vez, I.J. Lara-Navarro and A.R. Jaloma-Cruz
Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This stu.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048728
- DOI:
- 10.4238/gmr.15048728
Contribution of the GSTP1 gene polymorphism to the development of osteosarcoma in a Chinese population
Authors: W.R. Qu, J. Wu and R. Li
We conducted a case-control study to investigate the associations between GSTT1, GSTM1, and GSTP1 gene polymorphisms and development of osteosarcoma in a Chinese population. Between January 2013 and February 2015, 153 patients diagnosed with osteosarcoma and 252 control subjects were enrolled in the current study from the Orthopedic Hospital of the Second.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038034
- DOI:
- 10.4238/gmr.15038034
Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population
Authors: C.Y. Bai, X.Y. Shi, J. He, J. Xue and Y. Feng
We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038116
- DOI:
- 10.4238/gmr.15038116
Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimerâ??s disease
Authors: L. Ma and Z.N. Lu
In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer’s disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorph.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048740
- DOI:
- 10.4238/gmr.15048740
Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis
Authors: R. Yao, Y.Y. Du, Y.Z. Zhang, Q.H. Chen, L.S. Zhao and L. Li
Numerous studies have evaluated the association between the angiotensinogen ( AGT ) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature sea.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.4
- DOI:
- 10.4238/2015.May.25.4
Association between the CYP11B2 gene ??344T>C polymorphism and coronary artery disease: a meta-analysis
Authors: Y. Liu, H.L. Liu, W. Han, S.J. Yu and J. Zhang
Numerous studies have evaluated the association between the CYP11B2 gene ??344T>C polymorphism and coronary artery disease (CAD) risk. However, the specific association is still controversial. To address this issue, PubMed, EMBASE, and China National Knowledge Infrastructure databases were searched for eligible articles that reported on the relations.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.22
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.22
Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis
Authors: X.L. Zhang, X.J. Zhang, Y. Chen, Y.M. Zhang, Q. Zhang,C.X. Cao, D.Y. Gu, J.F. Shi, Y.L. Gong, J.F. Chen and C.J. Tang
A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was signifi cantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this p.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.10
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.10
Associations between TNF-?± polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis
Authors: Y.H. Lee and S.C. Bae
We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls... Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.6
- DOI:
- 10.4238/2015.May.25.6
Large-scale detection and application of expressed sequence tag single nucleotide polymorphisms in Nicotiana
Authors: Y. Wang, D. Zhou, S. Wang and L. Yang
Single nucleotide polymorphisms (SNPs) are widespread in the Nicotiana genome. Using an alignment and variation detection method, we developed 20,607,973 SNPs, based on the expressed sequence tag sequences of 10 Nicotiana species. The replacement rate was much higher than the transversion rate in the SNPs, and SNPs widely exist in the Nicotiana. In vitro .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.5
- DOI:
- 10.4238/2015.July.14.5