Polymorphism
Leptin and leptin receptor gene polymorphisms are correlated with production performance in the Arctic fox
Authors: M. Zhang and X.J. Bai
The polymerase chain reaction-single-strand conformation polymorphism technique was employed to measure mononucleotide diversity in the coding region of the leptin and leptin receptor genes in the Arctic fox. The relationships between specific genetic mutations and reproductive performance in Arctic foxes were determined to improve breeding strategies. We.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.7
- DOI:
- 10.4238/2015.May.25.7
Association of IL-4 promoter polymorphisms with asthma: a meta-analysis
Authors: L. Tang, H.G. Lin and B.F. Chen
This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that t.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.11
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.11
Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population
Authors: R.P. Lin, C.Y. Yao and D.X. Ren
Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 ca.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.25
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.25
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?
Authors: H.I. G�¶z�¼, S. ��z�§elik, M. Alo��lu, A. ��ahin, S. Temiz, A. Dayan, H. Cengiz, Y. T�¼t�¼nc�¼ and R. Bircan
The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkis.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038504
- DOI:
- 10.4238/gmr.15038504
Investigation of the association between matrix metalloproteinase-9 genetic polymorphisms and development of pre-eclampsia in Chinese pregnant women
Authors: C. Sun, Q. Zhang, B. Hu and K. Zhang
We carried out a case-control study to evaluate the role of MMP-9 -1562 C/T (rs3918242) genetic polymorphism in the risk of pre-eclampsia in Chinese pregnant women. Between March 2013 and January 2015, 107 pregnant women with pre-eclampsia were recruited from the Second Affiliated Hospital of Zhengzhou University. Genotyping of MMP-9 was carried out using.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038355
- DOI:
- 10.4238/gmr.15038355
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese
Authors: H.G. Wang, J.L. Wang, P. Chang, F.L. Cao4, X.C. Liu, Y.B. Ma, G.X. Zhai and H.Q. Gao
We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr946
- DOI:
- 10.4238/vol9-3gmr946
FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis
Authors: X.Q. Wu, S.M. Xu, Y.Q. Wang, Q. Li, Z.Q. Wang, C.L. Zhang and Y. Shen
Male infertility is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between follicle stimulating hormone receptor (FSHR) gene polymorphisms and male infertility risk has attracted widespread attention due to the unique biological functions of FSH. The ai.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.11
- DOI:
- 10.4238/2015.May.25.11
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis
Authors: T.T. Zhao, L.L. Shen, X.L. Zhang, D.Y. Gu, Q. Zhang, X.Y. Huo, C.J. Tang and J.F. Chen
Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.12
- DOI:
- 10.4238/2015.May.25.12
Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease
Authors: K. Wang, P.S. Dong, H.F. Zhang, Z.J. Li, X.M. Yang and H. Liu
We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 Ã?Â?174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polym.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.29
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.29
Polymorphisms in a myostatin gene and associations with growth in a hybrid of Culter alburnus and Ancherythroculter nigrocauda
Authors: L. Cheng and Y.H. Sun
Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in a hybrid of Culter alburnus (âÂ?Â?) x Ancherythroculter nigrocauda (âÂ?Â?) individuals from.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.13
- DOI:
- 10.4238/2015.May.25.13