Polymorphism
CCR2-64I is a risk factor for development of bladder cancer
Authors: K.F. Narter, B. Agachan, S. Sozen, Z.B. Cincin and T. Isbir
Chemokines are potent proinflammatory cytokines that are implicated in numerous inflammatory diseases. Proinflammatory gene polymorphisms lead to variations in the production and concentration of inflammatory proteins. We investigated a possible association between polymorphisms in chemokine and chemokine receptor genes (MCP-1.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr829
- DOI:
- 10.4238/vol9-2gmr829
Relationship between a lipoprotein lipase gene polymorphism in placental tissue and insulin resistance in patients with gestational diabetes mellitus
Authors: D.D. Li, D.Y. Su, L. Xue, W. Gao and W.Y. Pang
The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placenta.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.1
- DOI:
- 10.4238/2015.July.14.1
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, N. Syeed, M.Z. Banday, S.M. Bashir, B.A. Bhat and M.A. Siddiqi
Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to dete.. Read More»
- Genet. Mol. Res. 9(2):
- 0.4238/vol9-2gmr751
- DOI:
- 0.4238/vol9-2gmr751
IL-10 and IL-12B gene polymorphisms in a multiethnic Malaysian population
Authors: S.S. Sam, B.T. Teoh and S. AbuBakar
Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian popula.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.4
Genetic linkage between protein and DNA polymorphisms and antioxidant capacity of Cuminum cyminum L. accessions
Authors: E. Abdelhaliem and A.A. Al-Huqail
This study aimed to link the genetic variation observed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and random amplified polymorphic DNA (RAPD) analysis among 11 Cuminum cyminum L. accessions, collected from diverse ecogeographical areas in Saudi Arabia, with their antioxidant capacity to better .. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048916
- DOI:
- 10.4238/gmr.15048916
Rapid development of polymorphic microsatellite markers for the Amur sturgeon (Acipenser schrenckii) using next-generation sequencing technology
Authors: L.M. Li, L. Wei, H.Y. Jiang, Y. Zhang, X.J. Zhang, L.H. Yuan and J.P. Chen
Anthropogenic activities have seriously impacted wild resources of the Amur sturgeon, Acipenser schrenckii, and more information on local and regional population genetic structure is required to aid the conservation of this species. In this study, we report the development of 12 novel polymorphic microsatellite loci using next-generation sequencing techno.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.16
- DOI:
- 10.4238/2015.July.14.16
Usefulness of direct sequencing of pooled DNA for SNP identification and allele-frequency determination compatible with a common disease/common variant hypothesis
Authors: M.K. Kim, T.S. Nam, K.H. Choi, S.Y. Jang, Y.O. Kim and M.C. Lee
We examined the efficiency of direct sequencing of pooled DNA for developing common single nucleotide polymorphisms (SNPs) and its accuracy for estimating allele frequencies. A pool of 200 control DNAs was established and was used for developing SNPs and estimating minor allele frequencies (MAF). The sensitivity of the pooled .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr761
- DOI:
- 10.4238/vol9-2gmr761
Lack of association of ACE gene I/D polymorphism with obstructive sleep apnea syndrome in Turkish patients
Authors: T. Yakut, M. Karkucak, A. Ursavas, T. Gulten, B. Burgazlioglu, O. Gorukmez and M. Karadag
Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system, and there are reports in the literature describing its role in the development of cardiovascular system diseases, with I/D polymorphism of the ACE gene. We examined the relationship between a patient group with obstructive sleep .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr755
- DOI:
- 10.4238/vol9-2gmr755
DNA repair genes in endometriosis
Authors: R. Attar, C. Cacina, S. Sozen, E. Attar and B. Agachan
Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr779
- DOI:
- 10.4238/vol9-2gmr779
Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle
Authors: X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrell�³n, A.M.S. Rinc�³n, M.P. Bracamonte and W.A. Vera
The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr745
- DOI:
- 10.4238/vol9-2gmr745