Polymorphism
Association of beta 2 adrenoceptor gene polymorphisms in Malaysian hypertensive subjects
Authors: M. Komara, R. Vasudevan, P. Ismail, S.A. Bakar, S.R. Pishva and F. Heidari
The sympathetic nervous system plays a major role in blood pressure regulation. Beta 2 (β2) adrenoceptor gene polymorphisms have been associated with hypertension in different populations with conflicting results. We examined the association of three common polymorphisms, Arg16Gly, Gln27Glu, and Thr164Ile, of the β2 .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.2
- DOI:
- 10.4238/2014.April.16.2
Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis
Authors: L. Li, C. Wan and F.Q. Wen
X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association betwee.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.1
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.1
Isolation and characterization of polymorphic microsatellite loci in the swimming crab Portunus trituberculatus (Portunidae) L.P.
Authors: L.P. Ren, Y. Qin, X.C. Li, Y.N. Sun, R.X. Wang
The Swimming crab Portunus trituberculatus (Portunidae) is an important economically food species. To provide molecular markers for P. trituberculatus, we isolated and characterized polymorphic microsatellite markers. We developed a 5'-anchored genomic library of P. trituberculatus DNA, and derived 45 positive clones. We desig.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.19
- DOI:
- 10.4238/2013.November.22.19
Inter-retrotransposon-amplified polymorphism markers for germplasm characterization in Manihot esculenta (Euphorbiaceae)
Authors: A.M. Oliveira-Silva, G.F. Silva, M.C. Dias, C.R. Clement and N.R. Sousa
Manioc, Manihot esculenta, is economically important in many tropical and subtropical countries. The genetic variability of the species has not been fully explored, and new information may help expand its use. Molecular markers based on retrotransposons have good potential for analysis of genetic diversity given their abundanc.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.3
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.3
Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens)
Authors: X.Y. Wu1,2, C.N. Liang1,2, X.Z. Ding1,2, X. Guo1,2, P.J. Bao1,2, M. Chu1,2, W.B. Liu1,2 and P. Yan1,2
Vascular endothelial growth factor-A gene (VEGF-A) is a key regulator of angiogenesis and an endothelial cell mitogen that plays an important role in high-altitude adaptation. In this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) of VEGF-A by screening for genetic variation in 700 individuals of 3 domestic Chinese yak breeds - namely G.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.1
- DOI:
- 10.4238/2013.November.18.1
Genetic variants of the endothelial NO synthase gene (eNOS) may confer increased risk of sporadic congenital heart disease
Authors: K. Zhou, Y. Wang, W. Peng, J. Sun, Y.M. Qing and X.M. Mo
The endothelial NO synthase (eNOS) enzyme is expressed during the early stages of cardiogenesis and plays an important role in normal heart development. Genetic variations of eNOS G894T have been shown to influence individual susceptibility to some phenotypes of congenital heart disease (CHD) in different populations. We condu.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.4
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.4
Implication of polymorphisms in DNA repair genes with an increased risk of hepatocellular carcinoma
Authors: J.S. Wu, Y.P. Chen, L.C. Wang, Y.J. Yang, C.W. Deng, B.X. Hou, Z.L. He and J.X. Chen
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.5
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.5
Association of -238G/A and -863C/A polymorphisms in the TNF-�± gene with chronic obstructive pulmonary disease based on a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial b.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.10
- DOI:
- 10.4238/2013.October.24.10
Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response
Authors: J.A. Nastasi-Catanese1, J.R. Padilla-Guti�©rrez2, Y. Valle2, F. Ortega-Guti�©rrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6
Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 fa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.7
- DOI:
- 10.4238/2013.October.10.7
Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk
Authors: W.K. Zhou, L.Y. Huang, L. Hui, Z.W. Wang, B.Z. Jin, X.L. Zhao, X.Z. Zhang, J.X. Wang, J.C. Wang and R.Z. Wang
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.7