Polymorphism
Transferability of microsatellite markers of Capsicum annuum L. to C. frutescens L. and C. chinense Jacq.
Authors: S.I.C. Carvalho, C.F. Ragassi, I.B. Oliveira, Z.P.S. Amaral, F.J.B. Reifschneider, F.G. Faleiro and G.S.C. Buso
In order to support further genetic, diversity, and phylogeny studies of Capsicum species, the transferability of a Capsicum annuum L. simple sequence repeat (SSR) microsatellite set was analyzed for C. frutescens L. (“malagueta” and “tabasco” peppers) and C. chinense Jacq. (smell peppers, among other types). A total of 185 SSR pri.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.1
- DOI:
- 10.4238/2015.July.17.1
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Mining SNPs from EST sequences using filters and ensemble classifiers
Authors: J. Wang, Q. Zou and M.Z. Guo
Abundant single nucleotide polymorphisms (SNPs) provide the most complete information for genome-wide association studies. However, due to the bottleneck of manual discovery of putative SNPs and the inaccessibility of the original sequencing reads, it is essential to develop a more efficient and accurate computational method f.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr765
- DOI:
- 10.4238/vol9-2gmr765
Association between IL-4 gene polymorphisms, IL-4 serum levels, and ankylosing spondylitis
Authors: X.L. Liu, J.K. Ren and Y.L. Su
We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the c.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048898
- DOI:
- 10.4238/gmr15048898
Calpain-10 gene polymorphisms and risk of type 2 diabetes mellitus in Mexican mestizos
Authors: V.J. Picos-CÃ?¡rdenas , E. SÃ?¡inz-GonzÃ?¡lez , A. Miliar-GarcÃ?Âa ,A. Romero-Zazueta, R. Quintero-Osuna, E. Leal-Ugarte,V. Peralta-Leal and J.P. Meza-Espinoza
The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.6
- DOI:
- 10.4238/2015.March.27.6
IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies
Authors: J. Xu, L. Xu, L.T. Li, Q. You and L.S. Cha
Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 201.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.1
Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population
Authors: R. Lakhdar, S. Denden, J. Knani, N. Leban, H. Daimi, M. Hassine, G. Lefranc, J. Ben Chibani and A. Haj Khelil
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved i.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr770
- DOI:
- 10.4238/vol9-2gmr770
Association between IL6 polymorphism and risk of cerebral infarction
Authors: Y.H. Han
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. This study included 305 cerebral infarction patients and 326 control subjects enrolled between May 2012 and May 2014. The genotyping of IL6 -174G/C (rs1800795).. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Self-declared ethnicity and genomic ancestry in prostate cancer patients from Brazil
Authors: J.S. Oliveira, R.S. Ferreira, L.M. Santos, L.J. Marin, R.X. Corr�ªa, M.R. Luizon, A.L. Sim�µes, S.R. Gadelha and S.M.B. Sousa
Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-contro.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048769
- DOI:
- 10.4238/gmr15048769
Meta-analysis of angiotensin-converting enzyme insertion/deletion polymorphism and myocardial infarction in Han Chinese
Authors: W. Zhao, S.T. Ma and L.Q. Cui
It has been suggested that the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is linked to susceptibility to myocardial infarction (MI). In this study, we performed a meta-analysis to assess the relationship between ACE I/D polymorphism and MI in the Chinese Han population. Eight studies including a total of 1609 subjects w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.15
- DOI:
- 10.4238/2015.July.17.15