Polymorphism
GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
Authors: A.L. Oliveira, F.F.O. Rodrigues, R.E. Santos, T. Aoki, M.N. Rocha, C.A. Longui and M.B. Melo
The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associat.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr726
- DOI:
- 10.4238/vol9-2gmr726
Divergence and polymorphism analysis of IGF1Ra and IGF1Rb from orange-spotted grouper, Epinephelus coioides (Hamilton)
Authors: L. Guo, S. Yang, M.M. Li, Z.N. Meng and H.R. Lin
Orange-spotted grouper (Epinephelus coioides) is one of the most important marine fish and has a high market value. The insulin-like growth factor type 1 receptor (IGF1R) is a component of the insulin-like growth factor signaling system, and demonstrates important roles during growth. Based on information from livestock, we us.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048768
- DOI:
- 10.4238/gmr15048768
Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population
Authors: J. Guo, H.C. Lv, R.H. Shi and W.L. Liu
Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies
Authors: Q. Wang, N.Y. Wang, X.M. Cao, X. Sun, D. Shen, M. Yuan and J.F. Chen
Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A co.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038218
- DOI:
- 10.4238/gmr.15038218
Association between -44G/A and +71A/G polymorphisms in the connexin 40 gene and atrial fibrillation in Uyghur and Han populations in Xinjiang, China
Authors: J. Hailati, Y.C. Yang, L. Zhang, P.Y. He, M. Baikeyi, W. Muhuyati and Z.Q. Liu
We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polym.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048628
- DOI:
- 10.4238/gmr15048628
Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population
Authors: Y.X. Cui, H. Zhao and H.Q. Guo
In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recr.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048511
- DOI:
- 10.4238/gmr15048511
Association between interleukin-17A polymorphism and coronary artery disease susceptibility in the Chinese Han population
Authors: G.B. Su, X.L. Guo, X.C. Liu, Q.T. Cui and C.Y. Zhou
Coronary artery disease (CAD) is a major global health problem. In China, the incidence of CAD and the rate of mortality arising from it have increased every year. Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by activated T cells, and it may be involved in the development of CAD. Genetic polymorphisms in functional regions of the IL17A .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038235
- DOI:
- 10.4238/gmr.15038235
Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease
Authors: L. Wu, M.H. Zhao, G.Y. Geng, L. Mao and H.J. Liu
Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047823
- DOI:
- 10.4238/gmr15047823
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer
Authors: Alessandra D. Clarizia, Luciana Bastos-Rodrigues, HeloÃ?Âsa B. Pena, Charles Anacleto, Benedito Rossi, Fernando A. Soares, Ademar Lopes, JosÃ?© ClÃ?¡udio C. Rocha, OtÃ?¡via Caballero, Anamaria Camargo, Andrew J.G. Simpson and SÃ?©rgio D.J. Pena
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Conside.. Read More»
- Genet. Mol. Res. 5(2):
A novel polymorphic Alu insertion embedded in a LINE 1 retrotransposon in the human X chromosome (DXS225): identification and worldwide population study
Authors: Rinaldo Wellerson Pereira, Simone Silva dos Santos and S�©rgio Danilo Junho Pena
We describe a novel polymorphic Alu insertion (DXS225) on the human X chromosome (Xq21.3) embedded into an L1 retrotransposon. The DXS225 polymorphism was genotyped in 684 males from the CEPH Human Genome Diversity Panel. This insertion was found in all regions of the globe, suggesting that it took place before modern humans s.. Read More»
- Genet. Mol. Res. 5(1):