Polymorphism
Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration
Authors: Z.H. Tian, F. Shi, F.G. Zhong, D.P. Bai and X.Y. Zhang
The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial he.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.4
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.4
Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women
Authors: J. Shi, L.H. Li, X.Y. Duan, Q. Liu, L.L. Sun and Y.T. Tian
Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymor.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038332
- DOI:
- 10.4238/gmr.15038332
Pharmacogenetic role of XRCC1 polymorphisms on the clinical outcome of gastric cancer patients with platinum-based chemotherapy: a systematic review and meta-analysis
Authors: J. Xu, J. Ma, H.T. Zong, S.Y. Wang and J.W. Zhou
It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings... Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.6.2
- DOI:
- http://dx.doi.org/10.4238/2014.March.6.2
New strategy to detect single nucleotide polymorphisms
Authors: Miguel Galves, Jos�© Augusto Amgarten Quitzau and Zanoni Dias
A great effort has been made to identify and map a large set of single nucleotide polymorphisms. The goal is to determine human DNA variants that contribute most significantly to population variation in each trait. Different algorithms and software packages, such as PolyBayes and PolyPhred, have been developed to address this .. Read More»
- Genet. Mol. Res. 5(1):
Use of fluorescent-based amplified fragment length polymorphism to resolve phylogenetic relationships of Colchicum species from Turkey
Authors: ��. Karaka�� Metin, M. T�¼rkta��, F. Ertu��rul and E. Kaya
The study of phylogenetic relationships between 14 Colchicum taxa spread throughout Turkey was performed using a fluorescent-based amplified fragment length polymorphism (AFLP) technique. Five primer pair combinations were used in AFLP reactions. The data set was analyzed statistically using the NTSYS 2.1 software, and the nei.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.6.6
- DOI:
- http://dx.doi.org/10.4238/2014.March.6.6
Chloroplast DNA analysis of Tunisian cork oak populations (Quercus suber L.): sequence variations and molecular evolution of the trnL (UAA)-trnF (GAA) region
Authors: A. Abdessamad, G. Baraket, H. Sakka, Y. Ammari, M. Ksontini and A. Salhi Hannachi
Sequences of the trnL-trnF spacer and combined trnL-trnF region in chloroplast DNA of cork oak (Quercus suber L.) were analyzed to detect polymorphisms and to elucidate molecular evolution and demographic history. The aligned sequences varied in length and nucleotide composition. The overall ratio of transition/transversion (t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048749
- DOI:
- 10.4238/gmr15048749
Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population
Authors: J.B. Ma, L. Chen, B. Gao and J. Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048708
- DOI:
- 10.4238/gmr15048708
Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis
Authors: S. Zhao, X.M. Du, S.S. Ma and L.M. Wang
Numerous studies have evaluated the association between Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene and colorectal cancer (CRC) risk. However, the specific association remains controversial. To assess the relationship between the ALDH2 Glu504Lys polymorphism and CRC, we conducted a comprehensive meta-analysis of five case-control s.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037872
- DOI:
- 10.4238/gmr.15037872
eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease
Authors: A. Marin-Medina, A.J.L. Brambila-Tapia, V.J. Picos-C�¡rdenas, M.P. Gallegos-Arreola and L.E. Figuera
Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been st.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047802
- DOI:
- 10.4238/gmr15047802
Association of tumor necrosis factor-�± gene polymorphism with osteoarticular tuberculosis prognosis in a Hebei population
Authors: Y.J. Lv, S.J. Liu, W.N. Hu, G.P. Zhang, Q.Y. Ren, L.D. Zheng, Y.C. Zhang, R.Q. Li and Z.K. Zhang
This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048937
- DOI:
- 10.4238/gmr15048937