Polymorphism
Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population
Authors: Q. Pan Y. Ning L.Z. Chen S. Zhang Z.Z. Liu X.X. Yang W. Wei H. Wei Q.G. Li H.N. Yue J.X. Wang
Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.17.1
- DOI:
- 10.4238/2012.September.17.1
Genetic effect of the prolactin receptor gene on egg production traits in chickens
Authors: L. Zhang D.Y. Li Y.P. Liu Y. Wang X.L. Zhao Q. Zhu
The identification and utilization of potential candidate genes with significant effects on economically important traits have become increasingly important in poultry breeding programs. The prolactin (PRLR) receptor is a specific receptor for prolactin, which is an anterior pituitary peptide hormone involved in various physiological activities and is ess.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.2.1
- DOI:
- 10.4238/2012.October.2.1
Association of HTTLPR and 5-HT2A T102C polymorphisms with smoking characteristics and anthropometric profiles of Thai males
Authors: K. Suriyaprom B. Phonrat U. Chuensumran A. Tungtrongchitr R. Tungtrongchitr
Nicotine increases serotonin release in the brain. Gene polymorphisms in the serotonergic system have been suggested to be associated with smoking behavior. We investigated a possible association between two polymorphisms in the serotonergic system - HTTLPR of a serotonin transporter gene and 5-HT2Aat position T102C - with biochemical and anthropometric p.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.2
- DOI:
- 10.4238/2012.October.15.2
The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/p.Arg820Trp) is associated with psoriasis: a meta-analysis
Authors: G. Shi, S.J. Li, T.T. Wang, C.M. Cheng, Y.M. Fan and K.J. Zhu
Recent genetic evidence suggests a robust association of the CARD14 single nucleotide polymorphism rs11652075 (c.C2458T/p.Arg820Trp) and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. PubMed (MEDLINE), EMB.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038357
- DOI:
- 10.4238/gmr.15038357
Association between the -174 G/C polymorphism of the interleukin-6 gene and myocardial infarction risk: a meta-analysis
Authors: J. Zhou, J. Feng and X. Li
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 gene (IL6) and myocardial infarction (MI) risk. However, the results from the published studies are inconclusive. The aim of this meta-analysis was to determine whether the IL6 -174 G/C polymorphism is associated with MI risk. A meta-analysis based on ni.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038358
- DOI:
- 10.4238/gmr.15038358
DNA polymorphisms of the Hu sheep melanocortin-4 receptor (MC4R) gene associated with birth weight and 45d-weaning weight
Authors: X.M. Song J.F. Jiang G.Z. Zhang F.X. Shi Y.Q. Jiang
The melanocortin-4 receptor (MC4R) has important roles in regulating food intake, energy balance, and body weight in mammals. In pigs and cattle, MC4R mutations have been identified as genetic markers for growth and traits. Compared with abundant research conducted on other livestock species, little is known about mutations of the ovine MC4R gene. We inve.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.27.3
- DOI:
- 10.4238/2012.September.27.3
Development and testing of 13 polymorphic microsatellite markers in Larimichthys polyactis (Sciaenidae) using 5' anchored PCR
Authors: C.Y. Ma, H.Y. Ma and L.B. Ma
Larimichthys polyactis is a commercially important marine fish species in southeast Asia. The population crashed due to overfishing in the 1970s, but has since recovered. We developed 13 novel polymorphic microsatellite markers in L. polyactis using 5' anchored PCR. The characteristics of these loci were estimated by analyzing.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1464
- DOI:
- 10.4238/vol10-3gmr1464
Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results
Authors: G.G. Ceylan, C. Ceylan, B. G�¼lmemmedo ��. Tonyal�±, O. Odaba�� A. G�¶zalan, �°. Kele�� and E. ��zt�¼rk
Prostate cancer (PCa) is the most common type of neoplasm in European males. Genetic and epigenetic factors contribute to PCa development and progression. In this study, we aimed to assess the relationship between PCa and polymorphisms in the genes encoding endothelial nitric oxide synthase (eNOS), catalase (CAT), and myeloperoxidase (MPO). In total, 193 .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038543
- DOI:
- 10.4238/gmr.15038543
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China
Authors: Y.P. Liao, D. Zhang, W. Zhou, F.M. Meng, M.S. Bao, P. Xiang and C.Q. Liu
We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripher.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.4
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.4
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goi�¢nia
Authors: I.R. Costa, R.S. Mascarenhas, J.F. Corr�ªa, F.R.B. Oliveira, S.G. Fernandes, F.O. Souza, G.M. dos Reis, A. de P.R. J�ºnior, D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva and K.K.V.O. Moura
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amp.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038050
- DOI:
- 10.4238/gmr.15038050