Polymorphism
Polymorphisms in the bone morphogenetic protein 15 gene and their effect on sperm quality traits in Chinese Holstein bulls
Authors: L.P. Sun, Y.P. Song, Q.Z. Du, L.W. Song, Y.Z. Tian, S.L. Zhang,G.H. Hua and L.G. Yang
Bone morphogenetic protein 15 (BMP-15) expression has been detected in the testis, but its roles in this organ has not been well elucidated. We evaluated polymorphisms of the BMP-15 gene by PCR-SSCP and PCR-RFLP in 212 Chinese Holstein bulls, and investigated possible associations with sperm quality traits, including semen vol.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.8
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.8
A new single-nucleotide mutation (rs362719) of the reelin (RELN) gene associated with schizophrenia in female Chinese Han
Authors: W.J. Kuang, R.F. Sun, Y.S. Zhu and S.B. Li
Reelin is an extracellular signaling protein that plays an important role in the development of the central nervous system. Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. Genetic studies have also shown that mutations in the r.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1343
- DOI:
- 10.4238/vol10-3gmr1343
Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population
Authors: S. Honsawek, B. Deepaisarnsakul, A. Tanavalee, P. Yuktanandana, P. Bumrungpanichthaworn, S. Malila and N. Saetan
Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possi.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1161
- DOI:
- 10.4238/vol10-3gmr1161
Isolation and characterization of 19 polymorphic microsatellite loci from the topmouth gudgeon, Pseudorasbora parva
Authors: C. Zeng, Y. Gul, K. Yang, L. Cui, W.-M. Wang and Z.-X. Gao
The Asiatic topmouth gudgeon, Pseudorasbora parva, is recognized as one of the most invasive fish species in many countries outside of Asia. We isolated and characterized 19 microsatellite loci from P. parva. The polymorphism of these 19 loci was tested on 40 individuals of P. parva sampled from a wild population located in Ez.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1477
- DOI:
- 10.4238/vol10-3gmr1477
Association among oxidized LDL levels, MnSOD, apolipoprotein E polymorphisms, and cardiovascular risk factors in a south Brazilian region population
Authors: Maria G.V. Gottlieb, Carla H.A. Schwanke, Adriana F.R. Santos, Paulo F. Jobim, Denise P. M�¼ssel and Ivana B.M. da Cruz
Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic .. Read More»
- Genet. Mol. Res. 4(4):
Interleukin-10 promoter polymorphisms associated with susceptibility to lumbar disc degeneration in a Chinese cohort
Authors: W.P. Lin, J.H. Lin, X.W. Chen, C.Y. Wu, L.Q. Zhang, Z.D. Huang and J.M. Lai
We investigated a possible association between interleukin (IL)-10 single nucleotide polymorphisms (SNPs) and susceptibility to and severity of lumbar disc degeneration (LDD) in a Chinese cohort of 320 patients with LDD and 269 gender- and age-matched controls. The degree of disc degeneration was determined by magnetic resonan.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1283
- DOI:
- 10.4238/vol10-3gmr1283
Allele frequencies and genetic diversity in two groups of wild tufted capuchin monkeys (Cebus apella nigritus) living in an urban forest fragment
Authors: Jeanne Margareth Jimenes Amaral, Aguinaldo Luiz Sim�µes and David De Jong
There have been numerous studies genetically characterizing Old World Primates using microsatellites. However, few studies have been made of New World species and none on free-ranging Cebus apella, even though it is probably the most widely distributed species of monkey in the New World. The paucity of studies is due, in part,.. Read More»
- Genet. Mol. Res. 4(4):
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil
Authors: Rozany Mucha Dufloth, Sandra Costa, Fernando Schmitt and Luiz Carlos Zeferino
Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an.. Read More»
- Genet. Mol. Res. 4(4):
Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis
Authors: Y. Guan, L.H. Yan, X.Y. Liu, X.Y. Zhu, S.Z. Wang and L.M. Chen
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive met.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037969
- DOI:
- 10.4238/gmr.15037969
Association of IL-1�± gene polymorphism with susceptibility to type 1 diabetes in Chinese children
Authors: X. Zhou, J.G. Ca, H. Peng, J.L. Wang and G.M. Li
The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038025
- DOI:
- 10.4238/gmr.15038025