Polymorphism
HLA-G genetic variants and hepatocellular carcinoma: a meta-analysis
Authors: A.V.C. Coelho, R.R. Moura, S. Crovella and F. Celsi
Human leukocyte antigen (HLA)-G is a key tolerogenic molecule mainly expressed in the placenta and is crucial for implantation of the embryo and immunological tolerance of the fetus during pregnancy. However, under pathological conditions, such as cancer or viral infections, HLA-G can be expressed in other tissues. The gene coding for HLA-G (HLA-G, chromo.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038263
- DOI:
- 10.4238/gmr.15038263
Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population
Authors: S.C. Fan, J.G. Zhou and J.Z. Yin
We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was pe.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038268
- DOI:
- 10.4238/gmr.15038268
Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population
Authors: L.Q. Yang, Y. Zhang and H.F. Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038364
- DOI:
- 10.4238/gmr.15038364
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis
Authors: A.M. Barbosa, S.R. de Souza,, A.B. Frare, R.C. Costa e Silva, I.R. da Costa, K.S. Freitas e Silva, C.L. Ribeiro J�ºnior, B.M. Bordin and K.K.V.O. Moura
Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Soci.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038389
- DOI:
- 10.4238/gmr.15038389
Association of the genes for tumor necrosis factor-�± and myelin basic protein with delayed encephalopathy after acute carbon monoxide poisoning
Authors: S.G. Li W.Q. Li J.K. Wang H.Y. Zhang W. Li P. Zhang X.H. Wang H.X. Zhang J.P. Gu R.J. Gu
There is structural damage to myelin and secondary immune injury in the development of delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP). In order to assess the role of genetic factors in this mechanism, we studied the association between tumor necrosis factor-α308 (TNF-α308) and myelin basic protein (MBP) 5êÂ?Â?-side.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.19.1
- DOI:
- 10.4238/2012.December.19.1
TGF-�²1 polymorphisms and familial aggregation of liver cancer in Guangxi, China
Authors: P.Q. Wan, J.Z. Wu, L.Y. Huang, J.L. Wu, Y.H. Wei and Q.Y. Ning
The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.3
- DOI:
- 10.4238/2015.July.27.3
Association between polymorphism of �²3-adrenoceptor gene and overactive bladder: a meta-analysis
Authors: H.C. Qu, W. Zhang, Y.L. Liu and P. Wang
Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.7
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.7
Sexual genetic and simple sequence repeat (SSR) analysis for molecular marker development on the all hermaphrodite papaya
Authors: C.T. Chiu, C.W. Wang, F.C. Chen, S.W. Chin, C.C. Liu, M.J. Lee, W.C. Chung, Y.W. Chien, H.J. Chang and C.Y. Lee
The papaya (Carica papaya L.) is one of the most important economic tropical fruits in the world, and the hermaphrodite is the preferred type in field cultures. We analyzed the sexual ratio of offspring from the cultivar ‘Taiwan Seed Station No. 7’ (T7) by a self-cross and its cross with Taichung Sunrise (TS). Female progeny from the T7 self-c.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.8
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.8
Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer
Authors: W.X. Hu, C.M. Ding, R.J. Li, H.Y. Fan, Z.J. Guo and W. Liu
The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) pa.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.9
MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis
Authors: X.Y. Shi and Q. Shen
Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were ret.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.8
- DOI:
- 10.4238/2015.July.27.8