Polymorphism
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population J.
Authors: J.M. Liu, S.H. Cheng, C. Xia, T. Deng, Y.C. Zhu, X. Wei, Z.L. Huang, B.H. Liao, D.Y. Luo, Y.G. Zhang, T. Jin, K.J. Wang, J. Huang, H. Li
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated be.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019469
- DOI:
- 10.4238/gmr16019469
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis
Authors: J.H. Sung, B.E. Lee2, J.O. Kim2, Y.J. Jeon2, S.H. Kim1, S.W. Lim, J.Y. Moon, D.H. Cha, O.J. Kim, I.J. Kim and N.K. Kim
Coronary artery disease (CAD), a multifactorial disease, is a common cause of mortality in humans. Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>C, 4a4b, and 894G>T) have been previously associated with increased CAD risk. However, the sample size of this previous study was too small and limited to comprehensively define .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes
Authors: Y.L. Chen, D. Pei, Y.J. Hung, C.H. Lee, F.C. Hsiao, C.Z. Wu,J.D. Lin, C.H. Hsu, J.B. Chang and C.H. Hsieh
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjec.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.10
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.10
Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer
Authors: L.P. Chen, P.S. Cai and H.B. Liang
Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.15
- DOI:
- 10.4238/2015.July.27.15
Development and characterization of microsatellite markers via cross-species amplification of Paramisgurnus dabryanus
Authors: G. Chen, S. Huang, J. Gao, X. Bai, W. Wang and X. Cao
The large-scale loach, Paramisgurnus dabryanus, is a small freshwater fish of major economic importance in many Asian countries, particularly China and South Korea. Fifteen polymorphic microsatellite (simple sequence repeat) markers were obtained through cross-species amplification between this loach and a related species, Misgurnus anguillicaudatus (GenB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.1
- DOI:
- 10.4238/2015.May.29.1
Development and characterization of microsatellite markers for molecular genetic diversity in Atrina pectinata
Authors: Y.F. Ning, Z.B. Li, J.B. Shangguan, Y.S. Huang, P.D. Jiang, A.L. Xu and Y. Yuan
The pen shell, Atrina pectinata, is an economically valuable species that is widely distributed along the coastal waters of temperate and tropical areas, mainly growing in the Indian and Pacific Oceans. Eight novel microsatellite loci from the genome of A. pectinata were developed using fast isolation by amplified fragment length polymorphism of sequence .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.17
- DOI:
- 10.4238/2015.July.27.17
Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population
Authors: F.F. Yang Y. Huang Q.B. Li J.H. Dai Z. Fu
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with childhood asthma in a Chinese population. Genomic DNA was extracted f.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.19.1
- DOI:
- 10.4238/2012.October.19.1
Relationship between polymorphisms in exon 10 of FSHR gene and litter size in swine
Authors: X.D. Zhang, H.Y. Zhu, J. Zhou, N. Wang, N. Zhou, L. Huang, T. Wu, Y.F. Feng, Y.Y. Ding and Z.J. Yin
Follicle-stimulating hormone (FSH), a glycoprotein secreted by the anterior pituitary, can regulate ovarian function through the FSH receptor (FSHR). To evaluate the effects of the FSHR gene on reproductive traits in pigs, polymorphisms in exon 10 of the FSHR gene were observed by polymerase chain reaction-single-strand conformation polymorphism, and 3 si.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.13
- DOI:
- 10.4238/2015.July.27.13
Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma
Authors: G. Zhang, R. Bai, T. Zhang, H. Zhang, S.Z. Wen and D.M. Jiang
We conducted a case-control study in a Chinese population, and assessed whether the VEGF -634G/C, +936C/T, and +1612G/A polymorphisms could affect the risk of osteosarcoma and its association with environmental factors. A total of 180 consecutive osteosarcoma patients and 360 controls were included in our study. The genotypes of VEGF -634G/C, +936C/T, and.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.16
- DOI:
- 10.4238/2015.July.27.16
Screening relevant genes of tolerance to low phosphorus in maize using cDNA-amplified fragment length polymorphism
Authors: H.Y. Jiang, Z. Li, J. Zhao, Q. Ma, B.J. Cheng and S.W. Zhu
Soil contains a large amount of phosphorus, but plants cannot absorb most of this phosphorus effectively. Low inorganic phosphorus has been singled out as a major constraint that leads to a perpetually low Zea mays (maize) grain yield. The fundamental approach to solving this problem is to screen new genes of low phosphorous (LP) tolerance. Consequently, .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.5
- DOI:
- 10.4238/2015.May.29.5