Polymorphism
Development of swine-specific DNA markers for biosensor-based halal authentication
Authors: M.E. Ali, U. Hashim, M. Kashif, S. Mustafa, Y.B. Che Man and S.B. Abd Hamid
The pig (Sus scrofa) mitochondrial genome was targeted to design short (15-30 nucleotides) DNA markers that would be suitable for biosensor-based hybridization detection of target DNA. Short DNA markers are reported to survive harsh conditions in which longer ones are degraded into smaller fragments. The whole swine mitochondr.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.9
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.9
Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens).
Authors: M. Chu, X.Y. Wu, X. Guo, J. Pei, F. Jiao, H.T. Fang,C.N. Liang X.Z. Ding, P.J. Bao and P. Yan
Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.21
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.21
Vascular endothelial growth factor gene 1154 G/A, 2578 C/A, 460 C/T, 936 C/T polymorphisms and association with recurrent pregnancy losses
Authors: H. ��aml�±, B.��. Demir, A. ��zg�¶z, M.A. Atalay and G. Uncu
Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with liv.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.December.17.6
- DOI:
- 10.4238/2012.December.17.6
Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population
Authors: Q.Y. Chen, N. Liu, J. Ma, Y. Fang, Y. Cao, H. Li and Y.C. Liu
Clinical and experimental data have demonstrated that genetic factors play an important role in determining the susceptibility to ischemic stroke (IS). The present study was performed to clarify the association between the pre-microRNA-149 (miR-149) single nucleotide polymorphism rs71428439 and the risk of IS in the Jiangsu Han population. Polymerase chai.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.17
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.17
Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma
Authors: S. Wang, Y. Huang, R. Su, Z. Fang and M. Han
Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.2
- DOI:
- 10.4238/2015.June.1.2
Evaluation of the genetic diversity of Bupleurum using amplified fragment length polymorphism analysis
Authors: S.Y. Ke, L.L. Shi, Y.Z. Ma and X.J. Zhou
Radix bupleuri (Chaihu), the dried root of the Bupleurum plant, is an important component of traditional Chinese medicine. In this study, we examined the genetic diversity of 11 Bupleurum strains, originating from 7 provinces in China, using amplified fragment length polymorphism analysis. A total of 274 polymorphic bands were obtained using 6 primer comb.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.18
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.18
Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibility to keloids in the Chinese population
Authors: Y. Wu, B. Wang, Y.H. Li, X.G. Xu, Y.J. Luo, J.Z.S. Chen, H.C. Wei, X.H. Gao and H.D. Chen
Although there is evidence suggesting genetic susceptibility for keloids, studies investigating the association between Arg72Pro polymorphism in the P53 gene and tendency to form keloids have given variable results. We made a meta-analysis of the effects of P53 Arg72Pro polymorphism on keloid risk in the Chinese population by .. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.2
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.2
Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population
Authors: H.B. Gui, X.G. Du, Z.H. Fu and X.M. Chen
We investigate the relationship between IL-18 -607C/A and -137G/C genetic polymorphisms and development of acute pancreatitis in a Chinese population. A total of 153 patients were consecutively recruited from the First Affiliated Hospital of Chongqing Medical University between January 2013 and November 2014. Genotyping of IL-.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038394
- DOI:
- 10.4238/gmr.15038394
Association between TNF-�± rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis
Authors: X.P. Hua, J. Qian, C.B. Cao, J. Xie, X.T. Zeng and Z.J. Zhang
The tumor necrosis factor-alpha (TNF-α) G-308A polymorphism has been suggested to be a susceptibility factor for myocardial infarction (MI). However, differing results from various studies have led to controversial conclusions. Hence, we performed a meta-analysis to evaluate the association between TNF-α G-308A pol.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037292
- DOI:
- 10.4238/gmr.15037292
Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis
Authors: Y. Song, H.D. Gu, Y. He and J.W. Wang
We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.23
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.23