Polymorphism
miR-146a and miR-196a2 polymorphisms in ovarian cancer risk
Authors: X.C. Sun, A.C. Zhang, L.L. Tong, K. Wang, X. Wang, Z.Q. Sun and H.Y. Zhang
We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of mi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038468
- DOI:
- 10.4238/gmr.15038468
MicroRNA variants and colorectal cancer risk: a meta-analysis
Authors: X.M. Pan, X. Xiao, H.J. Qin, Z. Zhang, Z.H. Li, L.B. Gao and J. Jia
Colorectal cancer (CRC) is a multi-factorial disease, and genetic background may contribute to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may be used as specific markers of predisposition for CRC diagnosis and preventionIn this review, we summarize and discuss recent publications evaluating the .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038478
- DOI:
- 10.4238/gmr.15038478
Molecular cloning, characterization and association analysis of the promoter region of the bovine CDK6 gene
Authors: Y.F. Liu, L.S. Zan, W.T. Cui, Y.P. Xin, Y. Jiao and K. Li
Cyclin-dependent kinase 6 (CDK6) is a key element of D-type cyclin holoenzymes. It is involved in the regulation of the G1-phase of the cell cycle and is considered to be an important candidate gene for selection of body measurement traits through marker-assisted selection. We cloned the promoter sequence of this gene in bovin.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1466
- DOI:
- 10.4238/vol10-3gmr1466
Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows
Authors: M.P. Mullen, C.O. Lynch, S.M. Waters, D.J. Howard, P. O�Boyle, D.A. Kenny, F. Buckley, B. Horan and M.G. Diskin
The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1173
- DOI:
- 10.4238/vol10-3gmr1173
Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population
Authors: J.R. Xu, Y. Yang, X.M. Liu, J.Y. Sun and Y.J. Wang
The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.7
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.7
No evidence for association between DRD3 and COMT with schizophrenia in a Malay population
Authors: S.F. Tee, P.Y. Tang and H.C. Loh
Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We invest.. Read More»
- Genet. Mol. Res. 10(3):
STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer
Authors: B. Jiang, Z.Z. Zhu, F. Liu, L.J. Yang, W.Y. Zhang, H.H. Yuan, J.G. Wang, X.H. Hu and G. Huang
Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 po.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1071
- DOI:
- 10.4238/vol10-3gmr1071
KIR gene polymorphism study in the Uygur population in Xinjiang, China
Authors: G.-Y. Lin and Y.-B. Wang
We analyzed killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and genotype and haplotype characteristics in the Uygur population, a non-nomadic ethnic group found in Xinjiang, China, to provide a basis for studies on relationships between KIRs and diseases in this group. Sequence-specific primer PCR was used to detect the KIR gene in 84 Uy.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.9
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.9
Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population
Authors: Q.Y. Dong, X.M. Liu, C.G. Liang, W.H. Du, Y.L. Wang, W.X. Li and G.Q. Gao
Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of typ.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038559
- DOI:
- 10.4238/gmr.15038559
Frequency of the HFE C282Y and H63D polymorphisms in Brazilian malaria patients and blood donors from the Amazon region
Authors: F.R. Torres, W.C. Souza-Neiras, A.A. D�Almeida Couto,V.S.C. D�Almeida Couto, C.E. Cavasini, A.R.B. Rossit, R.L.D. Machado and C.R. Bonini-Domingos
Malaria is an endemic parasitosis and its causitive agent, Plasmodium, has a metabolism linked to iron supply. HFE is a gene with the polymorphisms C282Y and H63D, which are associated with a progressive iron accumulation in the organism leading to a disease called hereditary hemochromatosis. The aim of the present study was to determine the allelic and g.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr408
- DOI:
- 10.4238/vol7-1gmr408