Polymorphism
Association of SIRT2 gene polymorphisms with body measurement and growth traits of Qinchuan cattle
Authors: L.S. Gui, W.C. Yang, C.P. Zhao, S.J. Wei, Z.D. Zhao and L.S. Zan
Silent information regulator 2 (SIRT2), a member of the Sirtuin family of class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine SIRT2 gene and explore their relationships with meat quality and bod.. Read More»
- Genet. Mol. Res. 13(4):
Association of the estrogen receptor-�² gene RsaI and AluI polymorphisms with human idiopathic thin endometrium
Authors: A.W. Le, Z.H. Wang, R. Yuan, L.L. Shan, T.H. Xiao, R. Zhuo, Y. Shen
The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (cont.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.7
- DOI:
- 10.4238/2013.November.26.7
Association of BRCA2 variants with cardiovascular disease in Saudi Arabia
Authors: M. Alanazi, N.P. Reddy, J.P. Shaik, S.A. Ajaj, A.A.A. Jafari, H. Saeed, Z. Khan and A.P. Khan
Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a mult.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.13
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.13
Correlation of SPECT imaging, biochemical parameters and mutation with systolic dysfunction
Authors: D. Alenizi, N.A. Kizilbash, O. Gill, A. Abukanna, S. Malik, A. Badawy
We investigated systolic dysfunction by the use of biochemical laboratory tests and perfusion single-photon emission computed tomography imaging in 32 Pakistani subjects exhibiting symptoms of this disorder. To investigate underlying genetic causes, such as familial hypercholesterolemia, DNA samples from these subjects were sc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.6
- DOI:
- 10.4238/2013.November.26.6
BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males
Authors: K. Suriyaprom1, R. Tungtrongchitr2, K. Thawnashom1 and Y. Pimainog1
Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and ex.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.3
- DOI:
- 10.4238/2013.October.24.3
Relationship between dilated cardiomyopathy and the E23K and I337V polymorphisms in the Kir6.2 subunit of the KATP channel
Authors: H.L. Xi1*, J.F. Liu1*, L. Li2 and J. Wan1
ATP-sensitive potassium channels play an important role in myocardial electrical activity. Genetic disruption of these channels predisposes the myocardium to cardiac diseases. Herein we investigated whether two polymorphisms, E23K and I337V, located in the Kir6.2 subunit of ATP-sensitive potassium channels are associated with dilated cardiomyopathy (DCM) .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.4
- DOI:
- 10.4238/2013.October.10.4
Association of NPP1 polymorphism with postoperative progression of ossification of the posterior longitudinal ligament in Chinese patients
Authors: Z. He, H. Zhu, L. Ding, H. Xiao, D. Chen and F. Xue
Ossification of the posterior longitudinal ligament (OPLL) is a condition of the spine that can cause paralysis by compressing the spinal cord. The aim of this study was to evaluate the possible role of nucleotide pyrophosphatase phosphodiesterase 1 gene (NPP1) polymorphism in the etiology and pathology of the OPLL in Chinese patients. DNA from patients w.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.3
- DOI:
- 10.4238/2013.October.18.3
Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature
Authors: Y. Yang, H. Huang,W. Wang, L. Yang, L.L. Xie and W. Huang
The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyp.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.14
- DOI:
- 10.4238/2013.October.18.14
Comparative sodium dodecylsulfate-polyacrylamide gel electrophoresis and restricted fragment length polymorphism among fenugreek accessions
Authors: E.A. Haliem and A.A. Al-Huqail
Protein and DNA polymorphismswere surveyed among seven accessions of wild fenugreek (Trigonellafoenum-graecum L.) to estimate their genetic diversity and relationships. Samples were obtained from diverse ecogeographical areas in Saudi Arabia and Yemen. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of seed storage protein sh.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.16
- DOI:
- 10.4238/2013.December.4.16
Interleukin-1�² +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis
Authors: F.-L. Wu, L.-Y. Wang, Y.-Q Huang, W.-B. Guo, C.-D. Liu and S.-G. Li
The purpose of this meta-analysis was to determine whether genetic variants of the interleukin-1β[+3954 C>T (rs1143634)] (IL-1β +3954 C>T) gene polymorphisms were associated with orthodontic external apical root resorption (EARR). A meta-analysis was carried out using data entered into the PubMed and Embase electronic databases before Octo.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.6
- DOI:
- 10.4238/2013.October.18.6