Polymorphism
Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis
Authors: T. Yuan, C. Tang, M. Chen, S. Deng and P. Chen
Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.January.4.3
- DOI:
- 10.4238/2013.January.4.3
Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis
Authors: W. Cai, Z.T. Wang, J. Zhong and Y. Zhang
The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the all.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.April.26.1
- DOI:
- 10.4238/2013.April.26.1
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer
Authors: J.M. He, Y.D. Pu, Y.J. Wu, R. Qin, Q.J. Zhang, Y.S. Sun, W.W. Zheng and L.P. Chen
We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vita.. Read More»
- Genet. Mol. Res. 13(4):
Rabbit MSTN gene polymorphisms and genetic effect analysis
Authors: X.B. Qiao, K.Y. Xu, B. Li, X. Luan, T. Xia and X.Z. Fan
We analyzed meat samples of nine pure lines of rabbit and its 37 hybrid combinations by sequencing and single-strand conformation polymorphism techniques to explore genetic polymorphisms of all the three exon regions and part of the 5'-regulatory region of the myostatin (MSTN) gene. Thus, we detected a single nucleotide mutati.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.1
- DOI:
- 10.4238/2014.April.8.1
Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients
Authors: I.B. Han, A.E. Ropper, Y.J. Jeon, H.S. Park, D.A. Shin, Y.D. Teng, S.-U. Kuh and N.-K. Kim
Ossification of the posterior longitudinal ligaments (OPLL) has been considered to be associated with abnormalities of bone metabolism, and transforming growth factor-β1 (TGF-β1) has been demonstrated to affect the bone remodeling process. We investigated two SNPs of the TGF-β1 promoter (-509C>T; rs1800469) and exon 1 (869T>C; rs19820.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.26
- DOI:
- 10.4238/2013.February.28.26
Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis
Authors: L.Wang, Z.T. Wang, J.J. Hu, R. Fan, J. Zhou and J. Zhong
The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inco.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.2
- DOI:
- 10.4238/2014.April.8.2
Genetic polymorphisms of LPL and HL and their association with the performance of Chinese sturgeons fed a formulated diet
Authors: Y. He1*, D. Shen1*, X.F. Liang1, R.H. Lu1 and H. Xiao2
It is very important to investigate the reasons for the large individual differences in individual performance of food acceptance when using formulated diets for the successful culture of larvae and juveniles of the Chinese sturgeon Acipenser sinensis. Genetic differences of the mitochondrial control region were investigated by direct sequencing in two gr.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.4
- DOI:
- 10.4238/2013.October.15.4
Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population
Authors: G.L. Hong, X.Z. Chen, Y. Liu, Y.H. Liu, X. Fu, S.B. Lin and Q. Zhu
Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.9
- DOI:
- 10.4238/2013.December.4.9
Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people
Authors: Y.H. Liu, Y.W. Zhou, J.A.Yang, Z.G. Tu, S.Y. Ji, Z.Y. Huang and Z.J. Zhou
This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chinese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han o.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.4
- DOI:
- 10.4238/2014.April.8.4
Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis
Authors: K.H. Chen, L.L. Chen, W.G. Li, Y. Fang and G.Y. Huang
Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relation.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.8
- DOI:
- 10.4238/2013.December.4.8