Polymorphism
Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment
Authors: J. Song, L.Z. Wang, X. Li, T.P. Jiang, T.Z. An, M. Xu, X.P. Wu and S. Zhou
We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The ge.. Read More»
- Genet. Mol. Res. 13(4):
Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer
Authors: M. Qi, D.M. Liu, L.L. Pan and Y.X. Lin
Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify rel.. Read More»
- Genet. Mol. Res. 13(4):
Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma
Authors: C.R. Tanyel1, Z.B. Cincin2, B. Gokcen-Rohlig1, K. Bektas-Kayhan3, M. Unur3 and B. Cakmakoglu2
We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restric.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.20
- DOI:
- 10.4238/2013.November.18.20
Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis
Authors: Y.J. Zhang, X.P. Zhong, Y. Chen, S.R. Liu, G. Wu and Y.F. Liu
Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.3
- DOI:
- 10.4238/2013.February.28.3
Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk
Authors: J.J. Hu1*, Z.T. Wang 2* and B. Li1
Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Ty.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.2
- DOI:
- 10.4238/2013.October.15.2
Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population
Authors: L. Wang, Z-T. Wang, H-X. Zhang, J. Liu, S-Y. Lu, R. Fan, J. Zhou, L. Xia, Y-W. Sun, J. Zhong, and Y-Z. Yuan
Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was pe.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.6
- DOI:
- 10.4238/2014.April.3.6
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients
Authors: L. Han1,2, X.J. Xu1,2, X.H. Liang1,2 and J. Ma1,2
We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essentia.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.30.2
- DOI:
- 10.4238/2013.October.30.2
Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population
Authors: H.-P. Yang, J.-F. Liu, J. Rao, X.-M. Zhang, H.-L. Qian, X.-Q. Niu and Z.-L. Zhao
Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcin.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.10
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.10
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels
Authors: N. Liu1, J. Jiang1, Y.J. Song2, S.G. Zhao3, Z.G. Tong4, H.S. Song1, H. Wu1, J.Y. Zhu1, Y.H. Gu1, Y. Sun1, W. Hua1 and J.P. Qi1
Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation... Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.10
- DOI:
- 10.4238/2013.October.29.10
Mutational analysis of AXIN2, MSX1, and PAX9 in two Mexican oligodontia families
Authors: Y.D. Mu1,2, Z. Xu1, C.I. Contreras1, J.S. McDaniel1, K.J. Donly1 and S. Chen1
The genes for axin inhibition protein 2 (AXIN2), msh homeobox 1 (MSX1), and paired box gene 9 (PAX9) are involved in tooth root formation and tooth development. Mutations of the AXIN2, MSX1, and PAX9 genes are associated with non-syndromic oligodontia. In this study, we investigated phenotype and AXIN2, MSX1, and PAX9 gene variations in two Mexican famili.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.10.10
- DOI:
- 10.4238/2013.October.10.10