Proliferation
miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA
Authors: S.L. Li, X.H. Ma, J.F. Ji, H. Li, W. Liu, F.Z. Lu, S.T. Wu and Y. Zhang
A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover,.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048923
- DOI:
- 10.4238/gmr15048923
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Authors: Y.Q. Wang, Y. Cai and X.M. Zhong
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regula.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039256
- DOI:
- 10.4238/gmr16039256
miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN
Authors: J.W. Ling, P.R. Lu, Y.B. Zhang, S. Jiang and Z.C. Zhang
We aimed to investigate the biological role of miR-367 in uveal melanoma cell growth and migration, and the underlying mechanism responsible. Quantitative real-time polymerase chain reaction was performed to evaluate miR-367 expression in uveal melanoma tissue samples and cell lines. A miR-367 mimic, miR-367 inhibitor, and neg.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039067
- DOI:
- 10.4238/gmr16039067
MTA1 promotes cell proliferation via DNA damage repair in epithelial ovarian cancer
Authors: Q.Y. Yang1, J.H. Li2, Q.Y. Wang3, Y. Wu3, J.L. Qin3, J.J. Cheng3 and J. Qiu3
We examined whether metastasis-associated gene 1 (MTA1) promotes cell proliferation via DNA damage repair in ovarian cancer. MTA1 was successfully down-regulated using small interfering RNA in the epithelial ovarian cancer cell lines SKOV-3 and OVCAR-3. Cell growth was evaluated through MTT and colony formation assays. Fluorescence-activated cell sorting .. Read More»
- Genet. Mol. Res. 13(4):
Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts
Authors: Z.-Y. Wu, L. Lu, J. Liang, X.-R. Guo, P.H. Zhang and S.-J. Luo
The purpose of this study was to identify microRNAs (miRNAs) involved in keloid formation and determine their influence on the proliferation of keloid fibroblasts (KFs). Eight specimens each of resected keloid tissue and normal skin tissue were collected. miRNAs that are differentially expressed in keloid tissue and normal ski.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.2
- DOI:
- 10.4238/2014.April.14.2
Effects of metallothionein-3 and metallothionein-1E gene transfection on proliferation, cell cycle, and apoptosis of esophageal cancer cells
Authors: Z.Q. Tian, Y.Z. Xu, Y.F. Zhang, G.F. Ma, M. He and G.-Y. Wang
Metallothionein (MT)-3 has cell growth inhibitory activity, and is the only currently known MT subtype with unique physiological functions. The expression levels of MT-1E, a subtype of MT-1, were positively correlated with the degree of esophageal cancer malignancy. The present study aimed to investigate the effects of MT-3 and MT-1E gene transfection on .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.2
- DOI:
- 10.4238/2013.October.17.2
KDR gene silencing inhibits proliferation of A549cells and enhancestheir sensitivity to docetaxel
Authors: R. Wei and J.-P. Zang
We investigated the effects of kinase-domain insert containing receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to docetaxel. After designing and synthesizing the KDR siRNA sequence, the sequence was transfected into A549 cells using Lipofectamine 2000. The expression of KDR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.43
- DOI:
- 10.4238/2015.November.18.43
Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor
Authors: J.W. Wang, W.W. Cheng, T. Xu and Z.Y. Yang
We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. Th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.57
- DOI:
- 10.4238/2015.November.18.57
Effect of ABCE1-silencing gene, transfected by electrotransfer, on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells
Authors: X. Qu and L. Zhang
We investigated the effect of an ABCE1-silencing gene on the proliferation, invasion, and migration of human thyroid carcinoma SW579 cells. We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer to obta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.32
- DOI:
- 10.4238/2015.November.18.32
Role of death receptors in the regulation of hepatocyte proliferation and apoptosis during rat liver regeneration
Authors: Y. Zhou1,2, J.C. Xu2, Y.F. Jia1 and C.S. Xu1
The balance between hepatocyte proliferation and apoptosis is critical for liver homeostasis during liver regeneration. We created a rat liver regeneration model by partial hepatectomy (PH) to investigate the overall mechanism that regulates the proliferation and apoptosis of hepatocytes. The Rat Genome 230 2.0 Array was used to investigate changes in the.. Read More»
- Genet. Mol. Res. 14(4):
- 0.4238/2015.October.29.26
- DOI:
- 0.4238/2015.October.29.26