Proliferation
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells
Authors: Y. Deng, J. Sun and L.D. Zhang
The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody wa.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016826
- DOI:
- 10.4238/gmr.15016826
5-Fluorouracil induces apoptosis of colorectal cancer cells
Authors: J.T. Zhang1, W.L. Zhou2, C. He3, T. Liu1, C.Y. Li1 and L. Wang1
5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017326
- DOI:
- 10.4238/gmr.15017326
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746
Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones
Authors: D. Drakulic, A. Krstic and M. Stevanovic
SOX2, a universal marker of pluripotent stem cells, is a transcription factor that helps control embryonic development in vertebrates; its expression persists in neural stem/progenitor cells into adulthood. Considering the critical role of the SOX2 transcription factor in the regulation of genes required for self-renewal and p.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.9
- DOI:
- 10.4238/2012.May.15.9
Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-1 cells
Authors: D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphis.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.18
- DOI:
- 10.4238/2015.January.15.18
Effect of pregnancy on the proliferation of rat adipose-derived stem cells
Authors: J.N. Li, Y. Zhang, Y.F. Wang and J.Y. Chen
Stem cell therapy faces many problems including poor survival rates and low viability. Enhancing the biological functions of stem cells improves efficacy of therapies. Estrogen, whose levels are elevated during pregnancy, affects the properties of bone marrow mesenchymal stem cells. Evidence suggests that adipose-derived stem .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019059
- DOI:
- 10.4238/gmr16019059
JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
Authors: X. Liu, Y. Sun, L. Yue, S. Li, X. Qi, H. Zhao, Y. Yang, C. Zhang and H. Yu
Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner byactivating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039003
- DOI:
- 10.4238/gmr.15039003
In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA
Authors: R.W. Zhang, Z.G. Liu, Y. Xie, L.X. Wang, M.C. Li and X. Sun
The purpose of this study was to investigate the effect of the traditional Chinese medicine TanIIA on the viability, invasion, and metastasis of SW480 cells. SW480 cells were treated with TanIIA for 24 h, and MTT assays were performed to determine the effect of TanIIA on cell viability. Transwell transmembrane experiments were applied to test the effect o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039008
- DOI:
- 10.4238/gmr.15039008
Impact of BMMSCs from different sources on proliferation of CD34+ cells
Authors: R.F. Liu, J.Q. Li, R.X. Hou, R. Wang and K.M. Zhang
There are significant differences on the biological characteristics of bone marrow mesenchymal stem cells (BMMSCs), immunological response, and antigen-presenting functions between patients with psoriasis and normal subjects, but there are no significant differences in aborted fetuses. We examined the differences in BMMSCs between aborted fetuses and patient.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.22
- DOI:
- 10.4238/2015.January.23.22
Effect of miRNA-203 on cervical cancer cells and its underlying mechanism
Authors: X.Z. Yin, D.M. Zhao, G.X. Zhang and L. Liu
miRNA-203 is involved in the development and progression of various types of cancer. However, its role in cervical cancer remains unclear. The aim of this study was to investigate the effect of miRNA-203 on the proliferation and migration of HeLa cervical cancer cells, as well as survivin expression in these cells. A miRNA-203 primer probe was designed ac.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038680
- DOI:
- 10.4238/gmr.15038680