Proliferation
Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells
Authors: D.X. Li, J. Zhang, Y. Zhang, P.W. Zhao and L.M. Yang
Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-depe.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.17
Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity
Authors: M.Y. Li, M. Zhu, F. Feng, F.Y. Cai, K.C. Fan, H. Jiang, Z.Q. Wang and E.Q. Linghu
The human proto-oncogene long interspersed nucleotide acid element-1 (LINE-1) open reading frame-1 protein (ORF-1p) is involved in the progress of several cancers. The transcription factor ETS-1 can mediate the transcription of some downstream genes that play specific roles in the regulation of cancerous cell invasion and meta.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.13
- DOI:
- 10.4238/2014.April.14.13
MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer
Authors: Q.W. Li,T. Zhou, F. Wang,M. Jiang, C.B. Liu, K.R. Zhang, Q. Zhou, Z. Tian, K.W. Hu
It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using q.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.2
- DOI:
- 10.4238/2015.December.8.2
Equol promotes rat osteoblast proliferation and differentiation through activating estrogen receptor
Authors: J. Wang, J. Xu, B. Wang, F.R. Shu, K. Chen and M.T. Mi
Phytoestrogens have been suggested as alternative treatment for postmenopausal osteoporosis. Equol, a metabolite of daidzein, has been shown to inhibit bone loss in ovariectomized mice and rats. However, whether or not equol influences the formation of bone has not yet been investigated. Therefore, we investigated the effect o.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.21
- DOI:
- 10.4238/2014.July.4.21
Wnt/�?²-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1
Authors: B.Q. Cheng, Y. Jiang, Q. Zhu and W.G. Lin
Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our re.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.4
- DOI:
- 10.4238/2014.July.7.4
Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells
Authors: Y.P. Zhang, Y.Q. Li, Y.T. Lv and J.M. Wang
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentratio.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.9
- DOI:
- 10.4238/2015.February.6.9
Proliferation and differentiation of human osteoblasts from a type 2 diabetic patient in vitro
Authors: J. Li, C.Y. Liu, Y.F. Jiang, X.Z. Wei and J.U. Li
We investigated the proliferation and differentiation potential of human osteoblasts from a type 2 diabetic patient in vitro. Human osteoblasts were obtained from a healthy subject and a type 2 diabetic patient and were cultured in vitro using the tissue explant adherent method. Differences in cell morphology were observed under a phase contrast microscop.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.23
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.23
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells
Authors: D.Y. Chen and G.F. Su
Chronic inflammation develops in the retinal microvasculature under sustained hyperglycemia and is implicated in the pathogenesis of diabetic retinopathy. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 have been reported to promote pro-inflammatory cytokines, which are involved in the pathogenesis of proliferative diabe.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016920
- DOI:
- 10.4238/gmr.15016920
Expression and role of cyclophilin B in stomach cancer
Authors: D.Q. Meng, P.L. Li and M. Xie
We elucidated the expression of ciclosporin protein B (cyclophilin B) in stomach cancer tissue and the correlation between cyclophilin B and clinicopathological parameters, and determined the effect of cyclophilin B on growth and proliferation of stomach cancer cells. Pathological sections of stomach cancer and paracancerous tissue were collected for dete.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.5
- DOI:
- 10.4238/2015.May.22.5
Up-regulation of Id1 in peripheral blood of psoriatic patients
Authors: C. Ronpirin, M. Achariyakul, T. Tencomnao, J. Wongpiyabovorn and W. Chaicumpa
Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of th.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr963
- DOI:
- 10.4238/vol9-4gmr963