Proliferation
Effect of p53 gene polymorphism on functions of prostate cancer cells
Authors: N. Chi, Z.Z. Yun, Z.H. Tan, X.Z. Li, B.T.B.G. Chen, J. Liu, L.B. Xu, K.W. Ma, S.X. Li, J.F. Liu and C.X. Liu
Prostate cancer cells were transfected with plasmids [empty plasmids, wild-type pcDNA3.1-p53 (V/V), mutant type pcDNA3.1- p53 (G/G)] to analyze the effect of p53 gene polymorphisms on the proliferation, cycle, and apoptosis of prostatic cancer cells. Empty plasmids containing wild-type pcDNA3.1-p53 (V/V) and mutant type pcDNA3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.3
- DOI:
- 10.4238/2015.October.2.3
Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation
Authors: R. Wang, J. Zheng, D.-S. Zhang, Y.-H. Yang and Z.-F. Zhao
Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expres.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.7
- DOI:
- 10.4238/2015.July.3.7
Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and T.L. Dong
Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.28
- DOI:
- 10.4238/2015.July.3.28
Effects of ganglioside GM1 and neural growth factor on neural stem cell proliferation and differentiation
Authors: Q. Wang, Y.H. Song, Z. Tang, Z.P. Wang, Q. Xu and N. Bao
Neurogenesis, recovery from nerve injury, neurodegeneration, and Parkinson’s disease affect people’s health, yet the underlying molecular mechanisms remain elusive. Here, we investigated the effect of ganglioside GM1 and neural growth factor (NGF) on neural stem cell (NSC) proliferation and differentiation in vitro to provide a scientific basi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038376
- DOI:
- 10.4238/gmr.15038376
Branches of NF-�?ºb signaling pathway regulate hepatocyte proliferation in rat liver regeneration
Authors: C.F. Chang, W.M. Zhao, J.X. Mei, Y. Zhou, C.Y. Pan, T.T. Xu and C.S. Xu
Previous studies have demonstrated that the nuclear factor κB (NF-κB) pathway is involved in promoting cell proliferation. To further explore the regulatory branches and their sequence in the NF-κB pathway in the promotion of hepatocyte proliferation at the transcriptional level during rat liver regeneration, Rat Genome 230 2.0 array was.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.9
- DOI:
- 10.4238/2015.July.13.9
Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy
Authors: J.Y. Yang, J.S. Wang and H.B. Liu
To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthani.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.12
- DOI:
- 10.4238/2015.July.13.12
Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and X.Q. Yue
Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasionwere detected by MTT assay, flow c.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.20
- DOI:
- 10.4238/2015.July.17.20
Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms
Authors: S. Panthong, N. Boonsathorn and S. Chuchawankul
Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidat.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048886
- DOI:
- 10.4238/gmr15048886
Effects of glial cell line-derived neurotrophic factor and leukemia-inhibitory factor on the behavior of two calf testis germline stem cell colony types
Authors: P. Zheng, H. Huang, Y.G. Tian, Y. Zeng, E.O. Adegoke, X. Wang and G.X. Zhang
Germline stem cells are the only such capable of transmitting genetic information in vivo. The isolation and culture of these cells in vitro provide a unique model to understand sperm differentiation and hence, spermatogenesis and male fertility. In this study, we isolated, purified, and cultured germline stem cells from the t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048856
- DOI:
- 10.4238/gmr15048856
miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299
Authors: L. Zheng, Y.X. Qi, S. Liu, M.L. Shi and W.P. Yang
Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung ca.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048367
- DOI:
- 10.4238/gmr15048367