Proliferation
Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation
Authors: Q.H. Zhang, P. Xu, Y.X. Lu and H.T. Dou
Fibroblast growth factors (FGFs) play important roles in angiogenesis, wound healing, embryonic development, and endocrine signaling pathways. Increasingly, recent studies have reported aberrant FGF expression in various malignancies. However, the involvement of FGFs in cervical carcinoma pathogenesis remains unclear. We aimed.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049043
- DOI:
- 10.4238/gmr15049043
Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-�?ºB pathway and epithelial-mesenchymal transition
Authors: Z.M. Feng and S.M. Guo
The aim of this study was to investigate the expression of T-cell immunoglobulin mucin domain molecule-3 (Tim-3) in osteosarcoma tissues, and analyze its effect on cell proliferation and metastasis in an osteosarcoma cell line. Tim-3 mRNA and protein expression in osteosarcoma tissue was detected by reverse transcriptase-polym.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037844
- DOI:
- 10.4238/gmr.15037844
Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression
Authors: Z. Peng and Y. Zhang
Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027078
- DOI:
- 10.4238/gmr.15027078
MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation
Authors: W. Peng, Z.-Y. Chen, L. Wang, Z. Wang and J. Li
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.5
- DOI:
- 10.4238/2013.August.20.5
Inhibition of human chronic myelogenous leukemia K562 cell growth following combination treatment with resveratrol and imatinib mesylate
Authors: X.J. Wang and Y.H. Li
To investigate the effect of treatment with resveratrol combined with imatinib mesylate on human chronic myelogenous leukemia K562 cell growth inhibition and apoptosis, in vitro cultured human chronic myelogenous leukemia K562 cells were incubated with different concentrations of resveratrol and imatinib mesylate when the cells were in the logarithmic pha.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.17
- DOI:
- 10.4238/2015.June.11.17
Inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1
Authors: X. Wang, X.J. He, H.Q. Xu, Z.W. Chen and H.H. Fan
The aim of this study was to explore the inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1 and its mechanism. For this study, athymic nude mice were injected with either normal pituitary tumor RC-4B/C cells or LRIG1-transfected RC-4B/C cells. We then calculated the volume inhibition rate .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027681
- DOI:
- 10.4238/gmr.15027681
NDC80 promotes proliferation and metastasis of colon cancer cells
Authors: X.K. Xing, H.Y. Wu, H.L. Chen and H.G. Feng
Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods. Western .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028312
- DOI:
- 10.4238/gmr.15028312
MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer
Authors: H.C. Zhuo, Y.F. Song, J. Ye, G.X. Lai and D.L. Liu
MicroRNA-154 (miR-154) is dysregulated in some human malignancies and is correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Therefore, we explored the effects of miR-154 on NSCLC tumorigenesis and development. Using quantitative reverse transcription-po.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028173
- DOI:
- 10.4238/gmr.15028173
Branches of the NF-�?ºB signaling pathway regulate proliferation of oval cells in rat liver regeneration
Authors: W.M. Zhao, Y.L. Qin, Z.P. Niu, C.F. Chang, J. Yang, M.H. Li, Y. Zhou and C.S. Xu1,
The NF-kB (nuclear factor kB) pathway is involved in the proliferation of many cell types. To explore the mechanism of the NF-kB signaling pathway underlying the oval cell proliferation during rat liver regeneration, the Rat Genome 230 2.0 Array was used to detect expression changes of NF-kB signaling pathway-related genes in .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017750
- DOI:
- 10.4238/gmr.15017750
Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla
Authors: Q.-B. Zhang, W. Cao, Y.-R. Liu, S.-M. Cui and Y.-Y. Yan
The function of SIRT1 in the proliferation and osteoblastic differentiation of dental stem cells is unclear. The aim of this study was to assess the roles of SIRT1 in these processes using periodontal ligament stem cells (PDLSCs) and stem cells from apical papilla (SCAPs). A defined concentration of resveratrol, an SIRT1 activ.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15015234
- DOI:
- 10.4238/gmr.15015234