Proliferation
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
FOXO1 is a tumor suppressor in cervical cancer
Authors: B. Zhang, L.S. Gui, X.L. Zhao, L.L. Zhu and Q.W. Li
Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in ce.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.3
- DOI:
- 10.4238/2015.June.18.3
MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3
Authors: L. He, H. Yao, L.H. Fan, L. Liu, S. Qiu, X. Li, J.P. Gao and C.Q. Hao
We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.17
- DOI:
- 10.4238/2013.April.2.17
Role of adiponectin in adipose tissue wound healing
Authors: C.E. Jin, L. Xiao, Z.H. Ge, X.B. Zhan and H.X. Zhou
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.11
- DOI:
- 10.4238/2015.August.3.11
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma
Authors: Y.B. Ma, D.W. Song, R.H. Nie and G.Y. Mu
MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uvea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027935
- DOI:
- 10.4238/gmr.15027935
Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38 MAPK
Authors: G.X. Liu, J.C. Zhu, X.Y. Chen, A.Z. Zhu, C.C. Liu, Q. Lai and S.T. Chen
We examined whether erythropoietin (EPO) can inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) in the mouse bone marrow and its underlying mechanism. We separated and extracted mouse bone marrow MSCs and induced adipogenic differentiation using 3-isobutyl-1-methylxanthine, insulin, and dexamethasone. Different concentrations of EPO were .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.5
- DOI:
- 10.4238/2015.June.26.5
Tristetraprolin: a novel mediator of the anticancer properties of resveratrol
Authors: C. Li, C. Tang and G. He
Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027213
- DOI:
- 10.4238/gmr.15027213
Decreased miR-452 expression in human colorectal cancer and its tumor suppressive function
Authors: T. Tang, G.C. Zhang, C.F. Li, Y.F. Liu and W.Y. Wang
-.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027730
- DOI:
- 10.4238/gmr.15027730
Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma
Authors: Y. Bao, L. Peng, J. Ma, K. Liu and W. Li
Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.4
- DOI:
- 10.4238/2015.December.14.4
MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG
Authors: J.J. Li,W.H. Chan,W.Y. Leung,Y. Wang and C.S. Xu
Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequenci.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.30
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.30