Proliferation
Receptor for advanced glycation end-products (RAGE) is overexpressed in human osteosarcoma and promotes the proliferation of osteosarcoma U-2OS cells in vitro
Authors: Q. Zhang, Y. Jin, C.F. Zhao, W.J. Wang and G.Y. Liu
Osteosarcoma (OS) is an aggressive cancer of the long bones, and usually affects children and young adults. The receptor for advanced glycation end-products (RAGE) has recently been recognized as an oncogenic receptor that binds to different ligands, and promotes the progression of various cancers. However, little is known abo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027817
- DOI:
- 10.4238/gmr.15027817
Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells
Authors: L. Zhang, Y.H. Xie and B.R. Lin
We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferatio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.12
- DOI:
- 10.4238/2015.August.14.12
Aquaporin in the proliferation and apoptosis of diabetic myocardial cells
Authors: P.F. Zhao and M.J. Sun
The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.5
- DOI:
- 10.4238/2015.December.21.5
Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells
Authors: R.F. Liu, F. Wang, Q. Wang, X.C. Zhao and K.M. Zhang
Psoriasis is an inflammatory skin disease characterized by excessive proliferation and abnormal differentiation and apoptosis of keratinocytes (KCs). Mesenchymal stem cells (MSCs) from skin lesions of psoriasis patients demonstrate abnormal cytokine secretion, which may affect KC proliferation and apoptosis. Here, we explored how MSCs from skin lesions of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.49
- DOI:
- 10.4238/2015.December.21.49
Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma
Authors: L.Q. Zhang, S.L. Sun, W.Y. Li , Z. Feng, X.Y. Xu, Q.S. Zhuang and J. Fang
Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.19
- DOI:
- 10.4238/2015.December.23.19